Recombinant Human Ran GTPase Activating Protein 1, GST-tagged
Cat.No. : | RANGAP1-682H |
Product Overview : | Recombinant human RanGAP1 produced inE. coliis fused to a GST-tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | RANGAP1-682H |
Description : | RanGTPase-activating RanGAP1 was the first protein shown to be post-translationally modified with SUMO. In higher eukaryotes, the cellular localization of RanGAP1 is regulated by SUMOylation of its C-terminal domain. The target lysines of RanGAP1, as well as the C-terminus of mature SUMO-1, lie within mobile regions of the two proteins. Upon SUMOylation, RanGAP1 and SUMO-1 behave as "beads-on-a-string" joined by a flexible isopeptide tether and their structures and local dynamic features do not change significantly beyond the site of this covalent linkage. |
Source/Host : | E. coli. |
Application : | RanGAP1 acts as a very good control substrate for use in SUMOylation assays producing a product with a single SUMO modification as shown above. |
Long Term Storage : | -80°C. |
Gene Name : | RANGAP1 Ran GTPase activating protein 1 [ Homo sapiens ] |
Synonyms : | Ran GTPase activating protein 1; SD; Fug1; KIAA1835; MGC20266; RANGAP1; ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog; segregation distorter homolog (Drosophila); OTTHUMP00000198756; OTTHUMP00000198757; RanGAP1 |
Gene ID : | 5905 |
mRNA Refseq : | NM_002883 |
Protein Refseq : | NP_002874 |
MIM : | 602362 |
UniProt ID : | P46060 |
Chromosome Location : | 22q13 |
Pathway : | Cell Cycle, Mitotic |
Function : | GTPase activator activity; Ran GTPase activator activity; protein binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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