Recombinant Human Ring-box 1, His-tagged
Cat.No. : | RBX1-2389H |
Product Overview : | Recombinant Human Ring-box 1 is Expressed inE. coliwith a His tag. MW= 14kDa. |
- Specification
- Gene Information
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Cat. No. : | RBX1-2389H |
Description : | Cullin-based E3 ligases, such as SCF (Skp1-Cdc53-F-box protein), are a large family of multi-subunit ubiquitin ligases with diverse cellular functions, including the regulation of the cell cycle, of the DNA damage response, and of various transcription factors. These ligases are composed of one of six mammalian cullin homologs (Cul1, Cul2, Cul3, Cul4a, Cul4b, and Cul5), the Ring finger containing protein Rbx1/Roc1, and cullin homolog-specific adaptor and substrate recognition subunits. Activation of cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein NEDD8. This modification is catalyzed by the Rbx1 subunit. |
Source : | E. coli. |
Purity : | ≥98% (SDS-PAGE). |
Concentration : | 0.5mg/ml. |
Formulation : | Liquid. In 50mM TRIS, pH 8.0, Containing 50mM NaCl and 1mM DTT. |
Storage : | -80°C. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
Gene Name : | RBX1 ring-box 1 [ Homo sapiens ] |
Synonyms : | RBX1; ring-box 1; ROC1; RNF75; MGC1481; MGC13357; BA554C12.1 |
Gene ID : | 9978 |
mRNA Refseq : | NM_014248 |
Protein Refseq : | NP_055063 |
MIM : | 603814 |
UniProt ID : | P62877 |
Chromosome Location : | 22q13.2 |
Pathway : | Cell cycle; Nucleotide excision repair; Oocyte meiosis; Pathways in cancer; Renal cell carcinoma; Ubiquitin mediated proteolysis; TGF-beta signaling pathway; HIV Infection |
Function : | NEDD8 ligase activity;metal ion binding; protein binding; zinc ion binding |
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◆ Lysates | ||
RBX1-2450HCL | Recombinant Human RBX1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.
Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.
Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.
RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.
Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.
RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.
RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.
Customer Reviews (3)
Write a reviewEfficiency and precision, vital for research quality.
Critical for decision-making, accelerates research productivity.
Enhances research credibility, a cornerstone of our research.
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