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Recombinant Human Ring-box 1, His-tagged

Cat.No. : RBX1-2389H
Product Overview : Recombinant Human Ring-box 1 is Expressed inE. coliwith a His tag. MW= 14kDa.
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  • Gene Information
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Cat. No. : RBX1-2389H
Description : Cullin-based E3 ligases, such as SCF (Skp1-Cdc53-F-box protein), are a large family of multi-subunit ubiquitin ligases with diverse cellular functions, including the regulation of the cell cycle, of the DNA damage response, and of various transcription factors. These ligases are composed of one of six mammalian cullin homologs (Cul1, Cul2, Cul3, Cul4a, Cul4b, and Cul5), the Ring finger containing protein Rbx1/Roc1, and cullin homolog-specific adaptor and substrate recognition subunits. Activation of cullin-based ligases require the covalent modification of a conserved lysine residue in the cullin protein with the ubiquitin-like protein NEDD8. This modification is catalyzed by the Rbx1 subunit.
Source : E. coli.
Purity : ≥98% (SDS-PAGE).
Concentration : 0.5mg/ml.
Formulation : Liquid. In 50mM TRIS, pH 8.0, Containing 50mM NaCl and 1mM DTT.
Storage : -80°C. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Gene Name : RBX1 ring-box 1 [ Homo sapiens ]
Synonyms :
RBX1; ring-box 1; ROC1; RNF75; MGC1481; MGC13357; BA554C12.1
Gene ID : 9978
mRNA Refseq : NM_014248
Protein Refseq : NP_055063
MIM : 603814
UniProt ID : P62877
Chromosome Location : 22q13.2
Pathway : Cell cycle; Nucleotide excision repair; Oocyte meiosis; Pathways in cancer; Renal cell carcinoma; Ubiquitin mediated proteolysis; TGF-beta signaling pathway; HIV Infection
Function : NEDD8 ligase activity;metal ion binding; protein binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does RBX1 contribute to proteasome-mediated degradation? 12/28/2022

It facilitates the attachment of ubiquitin, directing proteins to the proteasome for breakdown.

What potential therapeutic applications arise from targeting RBX1 in diseases? 07/26/2022

Targeting RBX1 offers potential for treating diseases with dysregulated protein turnover, including cancer.

What is the impact of altered RBX1 activity on cancer development? 02/25/2022

Altered RBX1 activity is associated with cancer progression, influencing cell proliferation and survival.

What role does RBX1 play in cell cycle regulation? 12/22/2020

RBX1 plays a role in cell cycle control by regulating the degradation of key cycle-related proteins.

How do genetic variations in RBX1 affect cellular processes? 11/18/2019

Genetic mutations in RBX1 can lead to disruptions in protein turnover, affecting various cellular functions.

What is the primary role of RBX1 in protein ubiquitination? 05/13/2018

RBX1, a RING-finger protein, is crucial for tagging proteins with ubiquitin, marking them for degradation.

How does RBX1 interact with other components of the ubiquitin-proteasome system? 10/08/2017

RBX1 works with other ubiquitin-proteasome system components, orchestrating protein degradation.

Customer Reviews (3)

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03/01/2020

    Efficiency and precision, vital for research quality.

    11/02/2019

      Critical for decision-making, accelerates research productivity.

      04/04/2017

        Enhances research credibility, a cornerstone of our research.

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