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Active Recombinant Mouse Dll4 protein, His-tagged

Cat.No. : Dll4-2288M
Product Overview : Recombinant Mouse Dll4 protein(NP_062327.2)(Met1-Pro525), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Mouse
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Bio-activity : 1. Immobilized DLL4 Protein, Mouse, Recombinant (His Tag) at 2 μg/mL (100 μL/well) can bind NOTCH1 Protein, Mouse, Recombinant (ECD, hFc Tag),the EC50 is 5-30 ng/mL.2. Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is typically 1-5 µg/mL in the presence of 500 ng/mL recombinant human BMP2.
Molecular Mass : The secreted recombinant mouse DLL4 comprises 509 amino acids and has a calculated molecular mass of 55.7 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 68 kDa band in SDS-PAGE under reducing conditions.
Proteinlength : Met1-Pro525
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 96 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Dll4 delta-like 4 (Drosophila) [ Mus musculus ]
Official Symbol : Dll4
Synonyms : DLL4; delta-like 4 (Drosophila); delta-like protein 4; drosophila Delta homolog 4; Delta4;
Gene ID : 54485
mRNA Refseq : NM_019454
Protein Refseq : NP_062327

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What role does DLL4 play in vascular diseases, such as atherosclerosis? 03/27/2023

DLL4 is implicated in the regulation of vascular inflammation and plaque formation, making it a potential target for atherosclerosis treatments.

How does DLL4 contribute to Alzheimer's disease pathogenesis? 10/27/2022

DLL4 has been linked to Alzheimer's disease as it can influence amyloid-beta accumulation and the activation of microglia in the brain.

Can DLL4 be used as a biomarker for any diseases? 10/01/2021

DLL4 levels can serve as a potential biomarker in some diseases, such as certain cancers, where it may indicate disease progression.

What are the challenges in developing DLL4-targeted therapies? 01/20/2018

Challenges include potential side effects, the need for personalized treatment approaches, and the complexity of the Notch signaling pathway.

How does DLL4 affect tissue regeneration? 05/23/2017

DLL4 can modulate tissue regeneration by influencing stem cell behavior and promoting tissue repair processes.

Customer Reviews (3)

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07/29/2022

    They ensure a consistent and reliable supply of DLL4 protein, minimizing any potential disruptions in my experimental workflow.

    05/01/2021

      the manufacturer's commitment to scientific collaboration and knowledge sharing greatly enhances my research experience.

      12/09/2017

        This collaborative approach empowers me to integrate cutting-edge knowledge, explore innovative techniques, and expand the impact of my research.

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