Recombinant Human METAP2 protein, HA-tagged

• Cat.No.: METAP2-630H
• Product Overview: Recombinant Human METAP2(aa 1-478) fused with hemagglutinin (HA) tag (YPYDVPDYA) at N-terminal was expressed in Insect cells.

Specification

• Description: MetAP2 is a metalloenzyme that catalyzes removal of the N-terminal methionine from proteins, with the physiologically relevant metal thought to be either cobalt or manganese. Since it was identified as the target of the anti-angiogenic natural product fumagilin (Prod. No. BML-CT100), it has been studied for its involvement in cancer, angiogenesis, inflammation, and rheumatoid arthritis. Because of differing substrate specificities and kinetics it is not desirable to substitute bacterial methionine aminopeptidase for mammalian MetAP2.
• Source: Insect cells
• Species: Human
• Tag: HA
• Form: Liquid. In 20mM HEPES, pH 7.3, containing 150mM sodium chloride, 10% glycerol, 0.02% sodium azide, and 0.1mM CoCl2.
• Molecular Mass: ~70kDa
• Purity: ≥95% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -80 centigrade.
• Storage: Long Term Storage: -80 centigrade; Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80 centigrade.

Gene Information

• Gene Name: METAP2 methionyl aminopeptidase 2 [ Homo sapiens ]
• Official Symbol: METAP2
• Synonyms: METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2
• Gene ID: 10988
• mRNA Refseq: NM_006838
• Protein Refseq: NP_006829
• MIM: 601870
• UniProt ID: P50579
• Chromosome Location: 12q22
• Function: aminopeptidase activity; metal ion binding; metalloexopeptidase activity; peptidase activity