Catalog # or name ...
Rabbit Polyclonal antibody to Human BACE2.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimers disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the Down critical region of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
Synthetic peptide: CPEVVNDESSLVRHRWK, corresponding to amino acids 503-518 of Human BACE2.
Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Immunogen affinity purified
Preservative: 0.05% Sodium Azide Constituents: PBS, 1mg/ml BSA
Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
Belongs to the peptidase A1 family.
Antigen Gene Information
BACE2 beta-site APP-cleaving enzyme 2 [ Homo sapiens ]
BACE2; beta-site APP-cleaving enzyme 2; AEPLC; beta-secretase 2; ALP56; CEAP1; DRAP; ASP1; Aspartyl protease 1; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Memapsin 1; Membrane associated aspartic protease 1; ALP 56; ALP56; Asp 1; ASP21; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase; asp 1; memapsin-1; theta-secretase; beta secretase 2; aspartyl protease 1; 56 kDa aspartic-like protease; aspartic-like protease 56 kDa; down region aspartic protease; beta-site APP cleaving enzyme 2; Down syndrome region aspartic protease; transmembrane aspartic proteinase Asp1; membrane-associated aspartic protease 1; beta-site amyloid precursor protein cleaving enzyme 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; ASP1; BAE2; ASP21; CDA13;
Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
aspartic-type endopeptidase activity; peptidase activity;
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