Catalog # or name ...
paxillin encoding 356-558 aa was expressed in E. coli. It was fused
with a GST tag at the N-terminus.
Paxillin is a focal
adhesion protein and a substrate for several tyrosine kinases such
as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of
paxillin is affected by conditions that change cell-cell adhesion.
Paxillin associates tightly with FAK and Crk through its SH2 domain.
This interaction is independent of the extracellular matrix.
Although paxillin was initially discovered in fibroblasts, its
phosphorylation may also be important during neurite extension
human Lyn protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA,
20% Glycerol without BSA and Sodium Azide.
Assays• Western Blotting.
commassie blue stained gel, the purified recombinant protein shows a
band at 48 kDa (including GST).
Storage & Stability
Store vial at -20℃
to -80℃. When stored at the recommended temperature, this protein is
stable for 12 months.
PXN paxillin [ Homo sapiens ]
pathway; Focal adhesion; Leukocyte transendothelial migration;
Regulation of actin cytoskeleton; VEGF signaling pathway; Cell
junction organization; Muscle contraction; Signaling by EGFR
metal ion binding;
protein binding; vinculin binding; zinc ion binding
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