Recombinant Human Plasminogen Activator, Urokinase

• Cat.No.: PLAU-702H
• Product Overview: Recombinant Human Plasminogen Activator, Urokinaseis expressed inInsect cell culture. MW= 33,000 Da.

Specification

• Cat. No.: PLAU-702H
• Description: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.
• Source: Insect cell culture.
• Form: Frozen liquid.
• Buffer: 0.05M Sodium Acetate; 0.1M NaCl; 1mM EDTA; pH 5.0.
• Concentration: 2.5 mg/ml.
• Aliquot: 1 x 0.1 mg.
• Shipping Conditions: Dry ice.
• Storage: Store at -70°C.

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens ]
• Synonyms: PLAU; plasminogen activator, urokinase; ATF; UPA; URK; u-PA; U-plasminogen activator; urokinase-type plasminogen activator; plasminogen activator, urinary; EC 3.4.21.73
• Gene ID: 5328
• mRNA Refseq: NM_001145031
• Protein Refseq: NP_001138503
• MIM: 191840
• UniProt ID: P00749
• Chromosome Location: 10q24
• Pathway: Complement and coagulation cascades; Hemostasis
• Function: peptidase activity; serine-type endopeptidase activity