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Cat.No.
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CPBT-30726RH
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Product Overview
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Rabbit Polyclonal antibody to Human CYR61.
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Antigen Description
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The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
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Isotype
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IgG
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Immunogen
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A synthetic peptide corresponding to an internal region of human CCN1.
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Host
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Rabbit
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Species
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Human
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Formulation
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Liquid
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Applications
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IHC-P
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Storage buffer
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Preservative: 0.1% Sodium Azide Constituents: 1% BSA, 50mM Tris, pH 7.6
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Storage
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Store at +4oC. Do not freeze.
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Sequence similarities
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Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.
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Antigen Gene Information
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Gene Name
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CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens ]
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Official Symbol
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CYR61
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Synonyms
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CYR61; cysteine-rich, angiogenic inducer, 61; IGFBP10; protein CYR61; CCN1; GIG1; 3CH61; CCN 1; CCN family member 1; CYR 61; CYR61; CYR61 protein; CYR61_HUMAN; Cysteine rich angiogenic inducer 61; Cysteine rich heparin binding protein 61; Cysteine-rich angiogenic inducer 61; GIG 1; GIG1; IBP-10; IGF-binding protein 10; Igfbp 10; IGFBP-10; Igfbp10; Insulin like growth factor binding protein 10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10;
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GeneID
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3491
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mRNA Refseq
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NM_001554
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Protein Refseq
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NP_001545
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MIM
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602369
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Uniprot ID
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O00622
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Chromosome Location
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1p22.3
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Pathway
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Hypertrophy Model, organism-specific biosystem; Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; RhoA signaling pathway, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem;
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Function
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extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding;
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Download Datasheet:
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