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Recombinant Human Caspase 2, Apoptosis-related Cysteine Peptidase

Cat.No. : CASP2-747H
Product Overview : Recombinant human caspase-2 was expressed inE. colias a single polypeptide chain. MW = 12000 and 19000.
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Cat. No. : CASP2-747H
Description : Caspase 2 proteolytically cleaves other proteins. It belongs to a family of cysteine proteases called caspases that only cleave proteins at an amino acid following a aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. It is one of the most conserved caspases in different species of animal. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5 and caspase 9. It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. Pro-caspase-2 contains two subunits, p19 and p12.
Source : E.coli.
Purity : ≥90% by SDS-PAGE.
Form : Lyophilized solid.
Recommended Reaction Conditions : 50 mM HEPES, pH 7.2, 50 mM NaCl, 0.1% CHAPS (Cat. No. 220201), 10 mM EDTA, 5% glycerol, 10 mM DTT, and 200 µM peptide substrate. For analyzing caspase-2 activity, use 1 unit of enzyme per assay.
Specific Activity : ≥1500 units/mg protein.
Unit Definition : One unit is defined as the amount of enzyme that will cleave 1.0 nmol of Ac-VDVAD-pNA per h at 37°C, pH 7.2.
Solubility : PBS (0.1-1 unit/µl).
Toxicity : Standard Handling (MSDS available upon request).
Storage : ≤ -70℃. Following reconstitution, aliquot and freeze (-70℃). Stock solutions are stable for up to 6 months at -70℃.
Gene Name : CASP2 caspase 2, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms : CASP2; caspase 2, apoptosis-related cysteine peptidase; ICH1; NEDD2; CASP-2; ICH-1L; ICH-1L/1S; caspase-2; NEDD-2; ICH-1 protease; protease ICH-1; NEDD2 apoptosis regulatory; neural precursor cell expressed, developmentally down-regulated 2; neural precursor cell expressed developmentally down-regulated protein 2; EC 3.4.22.55; Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12
Gene ID : 835
mRNA Refseq : NM_032982
Protein Refseq : NP_116764
MIM : 600639
UniProt ID : P42575
Chromosome Location : 7q34-q35
Pathway : Signalling by NGF
Function : cysteine-type endopeptidase activity; enzyme binding; identical protein binding; peptidase activity; protein binding; protein domain specific binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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