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Recombinant Human CHUK, His-tagged

Cat.No. : CHUK-675H
Product Overview : Recombinant human full length CHUK, His-tagged was expressed ininsect cells.MW = 88.7 kDa.
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  • Gene Information
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Cat. No. : CHUK-675H
Description : Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in mediating the inflammatory response. In addition, IKK-α functions independently of the IκB kinase complex to regulate epidermal differentiation.
Source : Insect cells.
Formulation : Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2mM DTT + 50% glycerol.
Specific Activity : 38 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
Storage & Stability : Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
Gene Name : CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ]
Synonyms :
conserved helix-loop-helix ubiquitous kinase; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; ikappaB kinase; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; conserved helix-loop ubiquitous kinase; Nuclear factor NFkappaB inhibitor kinase alpha; nuclear factor NF-kappa-B inhibitor kinase alpha;Nuclear factor NF-kappa-B inhibitor kinase alpha; Transcription factor 16; IkappaB kinase; IKK-A; EC 2.7.11.10
Gene ID : 1147
mRNA Refseq : NM_001278
Protein Refseq : NP_001269
MIM : 600664
UniProt ID : O15111
Chromosome Location : 10q24-q25
Pathway : Acute myeloid leukemia; Adipocytokine signaling pathway; Apoptosis; B cell receptor signaling pathway; Chagas disease; Chemokine signaling pathway; Chronic myeloid leukemia; Cytosolic DNA-sensing pathway; Epithelial cell signaling in Helicobacter pylori infection; MAPK signaling pathway; NOD-like receptor signaling pathway; Pancreatic cancer; Pathways in cancer; Prostate cancer; RIG-I-like receptor signaling pathway; Shigellosis; Small cell lung cancer; T cell receptor signaling pathway; Toll-like receptor signaling pathway; Signaling in Immune system
Function : ATP binding; IkappaB kinase activity; identical protein binding; nucleotide binding; protein binding; protein heterodimerization activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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