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Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His

Cat.No. : IGF1R-2654H
Product Overview : Recombinant human IGF-1R was fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed inS. frugiperdainsect cells using a baculovirus expression system. MW = 76532 Da.
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  • Gene Information
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Cat. No. : IGF1R-2654H
Description : IGF-1R belong to the tyrosine kinase receptor family that mediates cell survival and growth in response to its ligands, IGF-1 and IGF-2. It is also involved in the proliferation of transformed cells.
Source : S. frugiperda.
Form : Liquid. In 100 mM NaCl, 50 mM Tris-HCL, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Specific Activity : ≥45 U/mg protein.
Unit Definition : One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Glu,Tyr)4:1 per min at 30°C using variable concentrations of ATP (0.1-2.52 µM).
Storage : ≤ -70℃. Avoid freeze/thaw.
Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
Synonyms : IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
Gene ID : 3480
mRNA Refseq : NM_000875
Protein Refseq : NP_000866
MIM : 147370
UniProt ID : P08069
Chromosome Location : 15q26.3
Pathway : Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer
Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which cellular compartments is IGF1R predominantly localized? 04/06/2022

IGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.

Are there specific downstream signaling pathways activated by IGF1R, and how do they influence cell proliferation and survival? 04/27/2021

Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.

How does IGF1R interact with insulin-like growth factors (IGFs) and insulin, and what is its role in growth regulation? 04/09/2020

IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.

Are there therapeutic implications or potential targets related to IGF1R in diseases involving growth signaling? 09/06/2019

There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.

What diseases or conditions are associated with dysregulation or abnormal expression of IGF1R? 09/24/2018

Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.

What is the primary function of Insulin-like growth factor 1 receptor (IGF1R) in cellular processes and growth signaling? 10/03/2016

Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.

How does IGF1R contribute to the regulation of tissue development, particularly in the context of growth and differentiation? 02/11/2016

IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.

Customer Reviews (3)

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Reviews
07/08/2022

    The product's exceptional purity facilitated precise quantification, ensuring data consistency.

    06/14/2019

      The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.

      04/29/2018

        The product's consistent performance bolstered the dependability of our research conclusions.

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