Recombinant Human Insulin-like Growth Factor 1 Receptor, GST-His
Cat.No. : | IGF1R-2654H |
Product Overview : | Recombinant human IGF-1R was fused at the N-terminus to a GST-His6-thrombin cleavage site sequence and expressed inS. frugiperdainsect cells using a baculovirus expression system. MW = 76532 Da. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IGF1R-2654H |
Description : | IGF-1R belong to the tyrosine kinase receptor family that mediates cell survival and growth in response to its ligands, IGF-1 and IGF-2. It is also involved in the proliferation of transformed cells. |
Source : | S. frugiperda. |
Form : | Liquid. In 100 mM NaCl, 50 mM Tris-HCL, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol. |
Specific Activity : | ≥45 U/mg protein. |
Unit Definition : | One unit is defined as the amount of enzyme required to transfer 1 nmol phosphate to Poly(Glu,Tyr)4:1 per min at 30°C using variable concentrations of ATP (0.1-2.52 µM). |
Storage : | ≤ -70℃. Avoid freeze/thaw. |
Gene Name : | IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] |
Synonyms : | IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain |
Gene ID : | 3480 |
mRNA Refseq : | NM_000875 |
Protein Refseq : | NP_000866 |
MIM : | 147370 |
UniProt ID : | P08069 |
Chromosome Location : | 15q26.3 |
Pathway : | Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer |
Function : | ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
IGF1R-2037R | Recombinant Rhesus Macaque IGF1R Protein, His (Fc)-Avi-tagged | +Inquiry |
IGF1R-299H | Recombinant Human IGF1R Protein, His and Strep-tagged | +Inquiry |
IGF1R-1391H | Recombinant Human IGF1R Protein, DDK-tagged | +Inquiry |
Igf1r-1223M | Recombinant Mouse Igf1r Protein, MYC/DDK-tagged | +Inquiry |
IGF1R-2588H | Recombinant Human IGF1R protein(1291-1360 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionIGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.
Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.
IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.
There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.
Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.
Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.
IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.
Customer Reviews (3)
Write a reviewThe product's exceptional purity facilitated precise quantification, ensuring data consistency.
The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.
The product's consistent performance bolstered the dependability of our research conclusions.
Ask a Question for All IGF1R Products
Required fields are marked with *
My Review for All IGF1R Products
Required fields are marked with *
Inquiry Basket