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Recombinant Human RB1, GST-tagged

Cat.No. : RB1-570H
Product Overview : Recombinant Human RB1, fused with N-terminal GST tag, was expressed in an E. coli expression system.
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Description : The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Source : E. coli
Species : Human
Tag : GST
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 18 mM Glutathione, 10% glycerol, and 3 mM DTT.
Molecular Mass : 43.5 kDa
Purity : ≥ 47%
Applications : Kinase substrate for the kinase assay; western blot
Storage : >6 months at –80°C
Gene Name : RB1 retinoblastoma 1 [ Homo sapiens ]
Official Symbol : RB1
Synonyms : RB1; retinoblastoma 1; RB; pRb; OSRC; pp110; p105-Rb; RB1; osteosarcoma; OTTHUMP00000018397; Rb; retinoblastoma suspectibility protein; retinoblastoma-associated protein
Gene ID : 5925
mRNA Refseq : NM_000321
Protein Refseq : NP_000312
MIM : 180200
UniProt ID : P06400
Chromosome Location : 13q14.2
Pathway : Bladder cancer; Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer;
Function : androgen receptor binding; kinase binding; phosphoprotein binding; transcription coactivator activity; transcription factor activity; transcription factor binding; transcription repressor activity; ubiquitin protein ligase binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of RB1 mutations on the development of retinoblastoma and other cancers? 02/14/2022

Mutations in RB1 lead to retinoblastoma and increase the risk of other cancers, disrupting normal cell cycle control.

How does RB1 interact with transcription factors and affect gene expression? 10/30/2021

RB1 interacts with transcription factors to regulate gene expression, impacting various cellular processes.

What role does RB1 play in DNA damage response and repair mechanisms? 02/25/2021

RB1 plays a crucial role in the DNA damage response, facilitating repair and maintaining genomic stability.

How does RB1 regulate the cell cycle, particularly the transition from G1 to S phase? 04/09/2020

RB1 controls the G1 to S phase transition in the cell cycle, preventing unregulated cell division.

How do alterations in RB1 expression or function influence stem cell differentiation and tissue regeneration? 10/25/2019

Changes in RB1 function affect stem cell differentiation and tissue regeneration, influencing tissue maintenance and repair.

What are the mechanisms by which RB1 modulates cellular senescence and apoptosis? 09/03/2019

RB1 influences cellular senescence and apoptosis, playing a role in aging and cell turnover.

How does RB1 contribute to tumor suppression and the prevention of uncontrolled cell proliferation? 02/17/2019

As a tumor suppressor, RB1 prevents excessive cell proliferation and contributes to cancer prevention.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient protein purification, delivers consistent yield and purity.

    01/19/2021

      Expertise in protein engineering, a trusted resource for research.

      10/09/2019

        Reliable protein crystallization services, exceptional results achieved.

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