Recombinant Human RAB4A, T7-tagged

• Cat.No.: RAB4A-2977H
• Product Overview: Recombinant Human RAB4A (1-213 aa) is expressed inE.Coliwith a T7 tag at N-terminus.

Specification

• Cat. No.: RAB4A-2977H
• Description: Dual-specific A-kinase-anchoring protein 2 (D-AKAP2/AKAP10), which interacts at its carboxyl terminus with protein kinase A and PDZ domain proteins, contains two tandem regulator of G-protein signaling (RGS) domains for which the binding partners have remained unknown. We show here that these RGS domains interact with Rab11 and GTP-bound Rab4, the first demonstration of RGS domains binding small GTPases. Rab4 and Rab11 help regulate membrane trafficking through the endocytic recycling pathways by recruiting effector proteins to specific membrane domains.
• Source: E.Coli.
• MW: 23871 Da.
• Purity: 95%.
• Formulation: 10 mM Tris. pH 8.0. 0.1% Triton X-100.0.002% NaN3. 10mM DTT.
• Application: MS. SDS.

Gene Information

• Gene Name: RAB4A RAB4A, member RAS oncogene family [ Homo sapiens ]
• Synonyms: RAB4A; RAB4A, member RAS oncogene family;Oncogene RAB4; RAB4, member RAS oncogene family; ras-related protein Rab-4A; HRES-1/RAB4; RAB4
• Gene ID: 5867
• mRNA Refseq: NM_004578
• Protein Refseq: NP_004569
• MIM: 179511
• UniProt ID: P20338
• Chromosome Location: 1q42-q43
• Pathway: Endocytosis
• Function: GDP binding; GTPase activity; ionotropic glutamate receptor binding; protein transporter activity; syntaxin binding