Catalog # or name ...
Sheep Polyclonal antibody to Human SCNN1A.
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synthetic peptide from the extracellular domain of human epithelial Sodium Channel alpha conjugated to an immunogenic carrier protein.
Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.
Preservative: None Constituents: Whole serum
Store at +4oC short term (1-2 weeks). Aliquot and store at -20oC (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
Antigen Gene Information
SCNN1A sodium channel, nonvoltage-gated 1 alpha [ Homo sapiens ]
SCNN1A; sodium channel, nonvoltage-gated 1 alpha; SCNN1; amiloride-sensitive sodium channel subunit alpha; ENaCalpha; Alpha ENaC 2; Alpha ENaC; Alpha NaCH; Alpha-ENaC; Alpha-NaCH; Amiloride sensitive epithelial sodium channel alpha subunit; Amiloride sensitive sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; Epithelial Na+ channel subunit alpha; FLJ21883; Nonvoltage gated sodium channel 1 subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN 1; SCNN1; SCNN1A; SCNNA_HUMAN; Sodium channel nonvoltage gated 1 alpha; alpha-ENaC; alpha-NaCH; alpha ENaC-2; epithelial Na(+) channel subunit alpha; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive epithelial sodium channel alpha subunit; BESC2; ENaCa; SCNEA;
Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem;
WW domain binding; actin binding; ion channel activity; ligand-gated sodium channel activity; protein binding;
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