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Cat.No.
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CPBT-33666SH
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Product Overview
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Sheep Polyclonal antibody to Human SCNN1A.
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Antigen Description
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Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Isotype
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IgG
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Immunogen
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Synthetic peptide from the extracellular domain of human epithelial Sodium Channel alpha conjugated to an immunogenic carrier protein.
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Host
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Sheep
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Species
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Human
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Specificity
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Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart.
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Formulation
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Liquid
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Purity Detail
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Whole antiserum
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Applications
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IHC-P, IHC-Fr
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Storage buffer
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Preservative: None Constituents: Whole serum
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Storage
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Store at +4oC short term (1-2 weeks). Aliquot and store at -20oC (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily.
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Antigen Gene Information
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Gene Name
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SCNN1A sodium channel, nonvoltage-gated 1 alpha [ Homo sapiens ]
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Official Symbol
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SCNN1A
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Synonyms
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SCNN1A; sodium channel, nonvoltage-gated 1 alpha; SCNN1; amiloride-sensitive sodium channel subunit alpha; ENaCalpha; Alpha ENaC 2; Alpha ENaC; Alpha NaCH; Alpha-ENaC; Alpha-NaCH; Amiloride sensitive epithelial sodium channel alpha subunit; Amiloride sensitive sodium channel subunit alpha; Amiloride-sensitive sodium channel subunit alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; Epithelial Na+ channel subunit alpha; FLJ21883; Nonvoltage gated sodium channel 1 subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN 1; SCNN1; SCNN1A; SCNNA_HUMAN; Sodium channel nonvoltage gated 1 alpha; alpha-ENaC; alpha-NaCH; alpha ENaC-2; epithelial Na(+) channel subunit alpha; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; amiloride-sensitive epithelial sodium channel alpha subunit; BESC2; ENaCa; SCNEA;
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GeneID
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6337
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mRNA Refseq
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NM_001159576
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Protein Refseq
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NP_001153048
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MIM
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600228
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Uniprot ID
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P37088
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Chromosome Location
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12p13
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Pathway
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Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem; Taste transduction, organism-specific biosystem; Taste transduction, conserved biosystem;
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Function
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WW domain binding; actin binding; ion channel activity; ligand-gated sodium channel activity; protein binding;
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Download Datasheet:
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