Catalog # or name ...
Goat Polyclonal antibody to Human LRRK2.
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
Synthetic peptide: C-ELAEKMRRTSV, corresponding to C terminal amino acids 2516-2526 of Human LRRK2.
Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
Immunogen affinity purified
WB, ELISA, IHC-P
pH: 7.30Preservative:0.02% Sodium azideConstituents:99% Tris buffered saline, 0.5% BSA
Store at +4oC short term (1-2 weeks). Aliquot and store at -20oC long term. Avoid repeated freeze / thaw cycles.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 12 LRR (leucine-rich) repeats.Contains 1 protein kinase domain.Contains 1 Roc domain.
Antigen Gene Information
LRRK2 leucine-rich repeat kinase 2 [ Homo sapiens ]
LRRK2; leucine-rich repeat kinase 2; PARK8, Parkinson disease (autosomal dominant) 8; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; AURA17; Dardarin; Leucine rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRRK 2; LRRK2; LRRK2_HUMAN; PARK 8; PARK8; RIPK7; ROCO 2; ROCO2; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN;
Parkinsons disease, organism-specific biosystem;
ATP binding; GTP binding; GTP-dependent protein kinase activity; GTP-dependent protein kinase activity; GTPase activator activity;
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