Goat Anti-Human LRRK2 Polyclonal Antibody

Cat.No.

CPBT-38110GH

Product Overview

Goat Polyclonal antibody to Human LRRK2.

Antigen Description

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Isotype

IgG

Immunogen

Synthetic peptide: C-ELAEKMRRTSV, corresponding to C terminal amino acids 2516-2526 of Human LRRK2.

Host

Goat

Species

Human

Specificity

Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.

Formulation

Liquid

Purity Detail

Immunogen affinity purified

Applications

WB, ELISA, IHC-P

Storage buffer

pH: 7.30Preservative:0.02% Sodium azideConstituents:99% Tris buffered saline, 0.5% BSA

Storage

Store at +4^oC short term (1-2 weeks). Aliquot and store at -20^oC long term. Avoid repeated freeze / thaw cycles.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.Contains 12 LRR (leucine-rich) repeats.Contains 1 protein kinase domain.Contains 1 Roc domain.

Antigen Gene Information