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Recombinant Human SIRT1, His-tagged

Cat.No. : SIRT1-658H
Product Overview : Recombinant Human SIRT1 is produced from human cDNA, expressed in E. coli. Sequence identical to that at Genbank accession #NM012238.
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  • Gene Information
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Description : This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 25 mM TRIS, pH 7.5, 100mM NaCl, 5mM DTT and 10% glycerol.
Molecular Mass : 82 kDa
Storage : -80°C
Gene Name : SIRT1 sirtuin 1 [ Homo sapiens (human) ]
Official Symbol : SIRT1
Synonyms : SIRT1; SIR2L1; sirtuin 1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1
Gene ID : 23411
mRNA Refseq : NM_001142498
Protein Refseq : NP_001135970
MIM : 604479
UniProt ID : Q96EB6
Chromosome Location : 10q21.3
Pathway : Amphetamine addiction; E2F transcription factor network; Energy Metabolism
Function : HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does SIRT1 play a role in tissue regeneration? 10/13/2022

Studies have found that SIRT1 plays an important role in tissue regeneration. Activation of SIRT1 can promote the proliferation and differentiation of stem cells, which contributes to tissue regeneration and repair.

Is SIRT1 related to autophagy? 08/31/2021

Activation of SIRT1 promotes autophagy, which helps to remove damaged organelles and proteins and maintain cell health.

What is the relationship between SIRT1 and mitochondrial function? 01/19/2021

SIRT1 regulates mitochondrial function. Activation of SIRT1 can improve mitochondrial metabolism and function, contributing to energy metabolism and cell survival.

What role does SIRT1 play in cancer? 07/21/2020

Studies have found that SIRT1 exerts carcinogenic effects in some cancers, but exerts anti-cancer effects in others. It depends on the type of cancer and environmental factors.

What is the potential of SIRT1 in drug development? 05/20/2020

SIRT1 has potential therapeutic value in drug development. The development of small molecule drugs targeting SIRT1 can be used to treat a variety of diseases, including aging, diabetes, cardiovascular diseases, and neurodegenerative diseases.

How does SIRT1 relate to other sirtuins? 01/08/2020

SIRT1 interacts and regulates with other sirtuins. For example, SIRT1 can regulate the expression and activity of other Sirtuins, and other Sirtuins can also regulate the activity of SIRT1.

Customer Reviews (3)

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Reviews
10/12/2021

    Resulting banding is clear and bright, much more than expected.

    10/09/2021

      SIRT1 has high safety, environmental protection and no pollution.

      01/03/2021

        The quality is so good. It saves a lot of time. Good.

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