Recombinant Human Flavin Containing Monooxygenase 5

• Cat.No.: FMO5-717H

Specification

• Cat. No.: FMO5-717H
• Description: Dimethylaniline monooxygenase [N-oxide-forming] 5 is an enzyme that in humans is encoded by the FMO5 gene. Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
• Source: baculovirus infected insect cells.
• Biochem/physiol Actions: FMO′s are responsible for catalyzing the oxygenation of a variety of xenobiotic and drug compounds including environmental pollutants and carcinogens, which demonstrate a nucleophilic nitrogen, sulfur, selenium, and phosphorous-containing moiety associated with their respective oxides. These enzymes are classified as Phase I or oxidative drug metabolism enzymes. FMO5 is the only FMO isoform expressed in both adult and fetal human liver.
• Application: FMO5 is the only FMO isoform expressed in both adult and fetal human liver.
• Physical Form: Solution in 100 mM potassium phosphate buffer, pH 7.4.
• Form: buffered aqueous solution (2.5 mg in 100 mM Potassium Phosphate Buffer).
• Storage Temp: -70°C.

Gene Information

• Gene Name: FMO5 flavin containing monooxygenase 5 [ Homo sapiens ]
• Synonyms: flavin containing monooxygenase 5; FMO5; dimethylaniline monooxygenase [N-oxide-forming] 5; FMO 5; dimethylaniline oxidase 5; hepatic flavin-containing monooxygenase 5; Hepatic flavin-containing monooxygenase 5; Dimethylaniline oxidase 5; EC 1.14.13.8
• Gene ID: 2330
• mRNA Refseq: NM_001144829
• Protein Refseq: NP_001138301
• MIM: 603957
• UniProt ID: P49326
• Chromosome Location: 1q21.1
• Pathway: Drug metabolism - cytochrome P450
• Function: FAD binding; NADP or NADPH binding; flavin-containing monooxygenase activity; monooxygenase activity