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Cat.No.
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CPBT-39851MH
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Product Overview
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Mouse Polyclonal antibody to Human METAP2.
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Antigen Description
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This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2.
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Isotype
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IgG
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Immunogen
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Full length Human Methionine Aminopeptidase 2, amino acids 1-478
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Host
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Mouse
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Species
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Human
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Formulation
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Liquid
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Purity Detail
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Protein A purified
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Applications
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WB, ICC/IF
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Storage buffer
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Preservative: NoneConstituents: 1X PBS, pH 7.2
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the peptidase M24A family.
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Antigen Gene Information
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Gene Name
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METAP2 methionyl aminopeptidase 2 [ Homo sapiens ]
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Official Symbol
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METAP2
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Synonyms
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METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; AI047573; AL024412; AU014659,; MGC102452; A930035J23Rik; Amp2; AMPM2_HUMAN; EIF 2 associated p67 homolog; EIF-2-associated p67; Initiation factor 2 associated 67 kDa glycoprotein; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MAP2; METAP 2; METAP2; Methionine aminopeptidase 2; Methionyl aminopeptidase 2; MGC127390; MGC53792; MNPEP; p67; p67eIF2; Peptidase M 2; Peptidase M2; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2;
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GeneID
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10988
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mRNA Refseq
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NM_006838
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Protein Refseq
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NP_006829
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MIM
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601870
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Uniprot ID
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P50579
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Chromosome Location
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12q22
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Function
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aminopeptidase activity; metal ion binding; metalloexopeptidase activity; peptidase activity;
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Download Datasheet:
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