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Cat.No.
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CPBT-41456RH
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Product Overview
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Rabbit Polyclonal antibody to Human NECAB3.
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Antigen Description
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The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
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Isotype
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IgG
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Immunogen
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Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 (MACAGLLTVC LLRPPAPQPQ PQTPRHPQLA PDPGPAGHTL FQDVFRRADK) of Human Neuronal calcium-binding protein.
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Host
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Rabbit
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Species
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Human
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Specificity
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Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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WB
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Storage buffer
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Preservative: NoneConstituents: 2% Sucrose, PBS
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Contains 1 ABM domain.Contains 1 EF-hand domain.
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Antigen Gene Information
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Gene Name
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NECAB3 N-terminal EF-hand calcium binding protein 3 [ Homo sapiens ]
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Official Symbol
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NECAB3
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Synonyms
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NECAB3; N-terminal EF-hand calcium binding protein 3; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein , APBA2BP, SYTIP2; N-terminal EF-hand calcium-binding protein 3; dJ63M2.4; dJ63M2.5; EF hand calcium binding protein 3; EFCBP3; NIP1; XB51; dJ63M2.4; dJ63M2.5; NECAB3; NIP1; SYTIP2; XB51; amyloid beta (A4) precursor protein binding, family A, member 2 binding protein; Amyloid beta A4 protein binding family A member 2 binding protein; Amyloid beta A4 protein-binding family A member 2-binding protein; APBA2BP; EFCBP3; N terminal EF hand calcium binding protein 3; N-terminal EF-hand calcium-binding protein 3; NECA3_HUMAN; Nek2 interacting protein 1; Nek2-interacting protein 1; Neuronal calcium binding protein 3; Neuronal calcium-binding protein 3; STIP3; Synaptotagmin interacting protein 2; X11L binding protein 51; X11L-binding protein 51; X11L-binding protein 51; Nek2-interacting protein 1; EF-hand calcium binding protein 3; neuronal calcium-binding protein 3; synaptotagmin interacting protein 2; neuronal calcium-binding protein NECAB3; synaptotagmin interacting protein STIP3; amyloid beta A4 protein-binding family A member 2-binding protein; amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein; STIP3; SYTIP2; APBA2BP;
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GeneID
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63941
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mRNA Refseq
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NM_031232
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Protein Refseq
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NP_112509
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MIM
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612478
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Uniprot ID
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Q96P71
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Chromosome Location
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20q11.21
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Function
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calcium ion binding; protein binding;
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Download Datasheet:
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