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Active Recombinant Human CA8 protein, His-tagged

Cat.No. : CA8-879H
Product Overview : Recombinant Human CA8 protein(NP_004047.3)(Met1-Gln290), fused with His tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, 15% glycerol, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its esterase activity. The specific activity is >100 pmoles/min/μg.
Molecular Mass : The recombinant human CA8 comprises 296 amino acids and has a predicted molecular mass of 33.8 kDa. It migrates as an approximately 37 kDa band in SDS-PAGE under reducing conditions.
Protein Length : Met1-Gln290
Purity : > 94 % as determined by SDS-PAGE
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CA8 carbonic anhydrase VIII [ Homo sapiens ]
Official Symbol : CA8
Synonyms : CA8; carbonic anhydrase VIII; CALS; carbonic anhydrase-related protein; CARP; CA-related protein; carbonate dehydratase; carbonic anhydrase-like sequence; CAMRQ3; CA-VIII; MGC99509; MGC120502;
Gene ID : 767
mRNA Refseq : NM_004056
Protein Refseq : NP_004047
MIM : 114815
UniProt ID : P35219

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there specific proteins or molecules known to interact with CA8? 11/17/2021

CA8 interacts with IP3Rs, affecting calcium signaling in neurons.

How does CA8's role differ from the enzymatically active carbonic anhydrase isoforms? 07/10/2021

Unlike enzymatically active isoforms, CA8 doesn't catalyze the hydration of CO2 but instead plays roles in neuronal signaling and function.

Are there genetic mutations in the CA8 gene that are linked to specific diseases? 01/06/2020

Mutations in CA8 have been linked to cerebellar ataxia, a movement disorder.

How does CA8 contribute to cellular processes, given its non-enzymatic nature? 09/15/2019

CA8 impacts calcium signaling in neurons, affecting neural communication and potentially influencing motor control.

What post-translational modifications are typical for CA8? 05/23/2019

Specific modifications, like phosphorylation, can be explored using mass spectrometry or targeted biochemical assays.

What is the primary function of CA8, considering it's a non-enzymatic member of the carbonic anhydrase family? 12/02/2017

CA8 acts as a stabilizer for inositol 1,4,5-trisphosphate receptors (IP3Rs) in neurons.

In which human tissues or cell types is CA8 predominantly expressed? 04/18/2017

CA8 is mainly expressed in the cerebellum, particularly in Purkinje cells.

Customer Reviews (3)

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10/17/2021

    Saves time with efficient sample processing and analysis.

    09/18/2021

      Dedicated to our research success and achievements.

      08/02/2021

        Quick and precise protein quantification services.

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