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Cat.No.
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CPBT-42929RH
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Product Overview
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Rabbit Polyclonal antibody to Human ALPP.
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Antigen Description
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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3 untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.
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Isotype
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IgG
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Conjugation
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PLAP
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Immunogen
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Recombinant protein fragment corresponding to a region within amino acids 163 - 357 of Human Placental alkaline phosphatase (PLAP).
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Host
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Rabbit
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Species
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Human
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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WB
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Storage buffer
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Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
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Storage
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Shipped at 4oC. Upon delivery aliquot and store at -20oC or -80oC. Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the alkaline phosphatase family.
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Antigen Gene Information
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Gene Name
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ALPP alkaline phosphatase, placental [ Homo sapiens ]
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Official Symbol
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ALPP
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Synonyms
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ALPP; alkaline phosphatase, placental; alkaline phosphatase, placental (Regan isozyme); alkaline phosphatase, placental type; Regan isozyme; placental type; Alkaline phosphatase; Alkaline phosphatase placental; Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; ALP; Alp1; ALPP; FLJ61142; Germ-cell alkaline phosphatase; nagao isozyme; OTTHUMP00000164354; PALP; Placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP; PLAP-1; PLAP1; PPB1_HUMAN; Regan isozyme; PLAP-1; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme; ALP; PALP; PLAP;
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GeneID
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250
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mRNA Refseq
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NM_001632
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Protein Refseq
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NP_001623
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MIM
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171800
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Uniprot ID
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P05187
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Chromosome Location
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2q37.1
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Pathway
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Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem;
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Function
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alkaline phosphatase activity; alkaline phosphatase activity; hydrolase activity; metal ion binding;
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Download Datasheet:
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