Recombinant Human F11 Receptor, His-tagged

• Cat.No.: F11R-788H
• Product Overview: Recombinant Human F11R protein (Gln 24- Tyr 213), fused with the His tag at the N-terminus, was expressed inHuman Cells.

Specification

• Cat. No.: F11R-788H
• Description: As a typeⅠtransmembrane receptor belonging to the immunoglobulin superfamily, the human JAM-A, also known as platelet adhesion molecule 1(PAM-1) and platelet F11 receptor, is the firstly identified member of the Junctional Adhesion Molecule (JAM) family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea in human.
• Source: Human Cells.
• Molecular Mass: The mature recombinant human JAM-A/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer comprises 453 amino acids and has a calculated molecular mass of 50 kDa. As a result of glycosylation, the rh JAM-A/Fc monomer migrates as an approximately 61kDa protein in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Ser 28.
• Purity: > 95% as determined by SDS-PAGE.
• Formulation: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH7.5.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Storage And Stability: Samples are stable for up to twelve months from date of receipt at -70⁰C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: F11R F11 receptor [ Homo sapiens ]
• Synonyms: F11R; F11 receptor; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1; junctional adhesion molecule 1; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; Platelet adhesion molecule 1; JAM-1; OTTHUMP00000027880; OTTHUMP00000027881; CD321 antigen; Platelet F11 receptor
• Gene ID: 50848
• mRNA Refseq: NM_016946
• Protein Refseq: NP_058642
• MIM: 605721
• UniProt ID: Q9Y624
• Chromosome Location: 1q21.2-q21.3
• Pathway: Cell adhesion molecules (CAMs); Epithelial cell signaling in Helicobacter pylori infection; Leukocyte transendothelial migration; Tight junction; Cell-cell adhesion systems; Hemostasis; Integrin cell surface interactions; Signaling in Immune system
• Function: protein binding