Active Recombinant Mouse Timp1 protein
Cat.No. : | Timp1-3285M |
Product Overview : | Recombinant Mouse Timp1 protein(NP_035723.2)(Met1-Arg205) was expressed in HEK293. |
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Source : | HEK293 |
Species : | Mouse |
Tag : | N/A |
Form : | Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Bio-activity : | Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2(R&D Systems, Catalog # ES001). The IC50 value is < 6 nM. |
Molecular Mass : | The secreted recombinant mouse TIMP1 consists of 181 amino acids and has a calculated molecular mass of 21 kDa. It migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions. |
Protein Length : | Met1-Arg205 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | Timp1 tissue inhibitor of metalloproteinase 1 [ Mus musculus ] |
Official Symbol : | Timp1 |
Synonyms : | TIMP1; tissue inhibitor of metalloproteinase 1; metalloproteinase inhibitor 1; EPA; TPA-S1; TPA-induced protein; erythroid-potentiating activity; collagenase inhibitor 16C8 fibroblast; tissue inhibitor of metalloproteinase-1; tissue inhibitor of metalloproteinases 1; Clgi; Timp; TIMP-1; MGC7143; |
Gene ID : | 21857 |
mRNA Refseq : | NM_001044384 |
Protein Refseq : | NP_001037849 |
Products Types
◆ Recombinant Protein | ||
TIMP1-5733R | Recombinant Rat TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TIMP1-1034M | Recombinant Mouse TIMP1 Protein, His-tagged | +Inquiry |
TIMP1-4536R | Recombinant Rhesus Macaque TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Timp1-6436M | Active Recombinant Mouse Timp1 Protein, His-tagged | +Inquiry |
TIMP1-001H | Recombinant Human TIMP1 Protein, MBP-tagged | +Inquiry |
◆ Native Protein | ||
TIMP1-92H | Native Human TIMP-1 | +Inquiry |
TIMP1-30840TH | Native Human TIMP1 | +Inquiry |
TIMP1-91B | Active Native Bovine Thrombin | +Inquiry |
◆ Lysates | ||
TIMP1-2376MCL | Recombinant Mouse TIMP1 cell lysate | +Inquiry |
TIMP1-1490RCL | Recombinant Rat TIMP1 cell lysate | +Inquiry |
TIMP1-2678HCL | Recombinant Human TIMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.
TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.
FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.
TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.
TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.
Customer Reviews (3)
Write a reviewThe efficient delivery of this product ensured that our research timelines were met without any complications.
Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.
This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.
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