Recombinant Human Activin A Receptor, Type I

• Cat.No.: ACVR1-2595H
• Product Overview: Recombinant Human Activin A Receptor, Type I is expressed inBTI-Tn-5B1-4 cells.

Specification

• Cat. No.: ACVR1-2595H
• Description: Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
• Source: BTI-Tn-5B1-4 cells.
• Purity: Greater than 98% (determined by SDS-PAGE and HPLC analysis).
• Molecular Mass: 25.6 kDa.
• Specific Activity: ≥5 x 10⁵IU/mg.
• Endotoxin Level: < 0.1 ng per μg of rHu Activin A (1 EU/μg).
• Biological Activity: The ED₅₀as determined by its ability to inhibit the proliferation of murine MPC-11 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 10⁵units/mg.
• Formulation: Lyophilized from a sterile-filtered solution with no additives.
• Reconstitution: Please Note: Always centrifuge product briefly before opening vial. The lyophilized protein should be reconstituted in sterile, ultra-pure water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at -20°C for future use.
• Storage: The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted rHu Activin B should be used immediately or stored long-term in undiluted working aliquots at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: ACVR1 activin A receptor, type I [ Homo sapiens ]
• Synonyms: ACVR1; activin A receptor, type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2; OTTHUMP00000204604; OTT HUMP000002 04626; hydroxyalkyl-protein kinase; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
• Gene ID: 90
• mRNA Refseq: NM_001105
• Protein Refseq: NP_001096
• MIM: 102576
• UniProt ID: Q04771
• Chromosome Location: 2q23-q24
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; activin binding; activin receptor activity, type I; follistatin binding; gnesium ion binding; manganese ion binding; nucleotide binding; protein homodimerization activity; receptor activity; transferase activity; transforming growth factor beta binding