Recombinant Human TNFRSF17

• Cat.No.: TNFRSF17-2604H
• Product Overview: Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 17 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 5.3 kDa. The TNFRSF17 is purified by standard chromatographic techniques.

Specification

• Cat. No.: TNFRSF17-2604H
• Description: TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI.
• Source: E.Coli.
• Purity: Greater than 98% as determined by SDS-PAGE.
• Sequence: AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Formulation: 1mg of TNFRSF17 Human contains 20mM PBS, pH-7.4, and 130mM NaCl.
• Solubility: It is recommended to reconstitute the lyophilized TNFRSF17 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
• Storage: Lyophilized TNFRSF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFRSF17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
• Synonyms: TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B-cell maturation protein
• Gene ID: 608
• mRNA Refseq: NM_001192
• Protein Refseq: NP_001183
• MIM: 109545
• UniProt ID: Q02223
• Chromosome Location: 16p13.1
• Pathway: Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production
• Function: protein binding; receptor activity; tumor necrosis factor receptor activity