Recombinant Human PTK2B, GST-tagged

• Cat.No.: PTK2B-743H
• Product Overview: Recombinant Human PTK2B with GST tag is expressed in Baculovirus.

Specification

• Cat. No.: PTK2B-743H
• Description: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
• Source: Baculovirus.
• Purity: 74 %, The purity was assessed by SDS-PAGE/CBB staining.
• Storage And Handling: Store at -80oC. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: PTK2B PTK2B protein tyrosine kinase 2 beta [ Homo sapiens ]
• Synonyms: PTK2B; PTK2B protein tyrosine kinase 2 beta; PTK2B protein tyrosine kinase 2 beta; CAK beta; calcium-dependent tyrosine kinase; cell adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; related adhesion focal tyrosine kinase; EC 2.7.10.2
• Gene ID: 2185
• mRNA Refseq: NM_004103
• Protein Refseq: NP_004094
• MIM: 601212
• UniProt ID: Q14289
• Chromosome Location: 8p21.1
• Pathway: Calcium signaling pathway; Chemokine signaling pathway; GnRH signaling pathway; Leukocyte transendothelial migration; Natural killer cell mediated cytotoxicity
• Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein complex binding; signal transducer activity; transferase activity