Recombinant Human TIMP Metallopeptidase Inhibitor 1
Cat.No. : | TIMP1-2886H |
Product Overview : | Recombinant Human TIMP1 is expressed in Sf9 cells. |
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- Gene Information
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Cat. No. : | TIMP1-2886H |
Description : | The tissue inhibitor of metalloproteinases (TIMP-1) is a glycoprotein with a molecular mass of about 28-kDa. The secreted protein consists of 184 amino acids, six disuilfide bonds and two glycosylation sites containing N-linked oligosaccharides. TIMP-1 specifically inhibits the extracellular-matrix-degrading metalloproteinases such as collagenase, gelatinase and stromelysin. It has no activity on mammalian membrane metallo-proteinases, procollagen peptidase, or on bacterial metalloproteinases such as thermolysin. |
Source : | Sf9 cells. |
Form : | Liquid, in 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl2; 1 μM ZnCl2; 0.05% Brij 35; 0,05% NaN3. |
Specific Activity : | It is recommended to perform a pre-incubation of about 20 min / 37°C which allows the formation of the enzyme-inhibitor complex. |
Purity : | >92%, homogenous by electrophoresis and western blotting analysis. |
Stability And Storage : | The TIMP-1 is very stable if stored at -70°C and can be kept at –20°C for several months and at 4°C for weeks without significant loss of activity. Repeated freezing and thawing should be avoided. |
Gene Name : | TIMP1 TIMP metallopeptidase inhibitor 1 [ Homo sapiens ] |
Synonyms : | TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; FLJ90373; tissue inhibitor of metalloproteinase 1; erythroid potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); Tissue inhibitor of metalloproteinases; TIMP-1; Collagenase inhibitor; OTTHUMP00000023214; Erythroid-potentiating activity |
Gene ID : | 7076 |
mRNA Refseq : | NM_003254 |
Protein Refseq : | NP_003245 |
MIM : | 305370 |
UniProt ID : | P01033 |
Chromosome Location : | Xp11.3-p11.23 |
Function : | enzyme inhibitor activity; metalloendopeptidase inhibitor activity; protein binding |
Products Types
◆ Recombinant Protein | ||
TIMP1-4491H | Recombinant Human TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Timp1-01M | Recombinant Mouse Timp1 Protein, His-tagged | +Inquiry |
TIMP1-0058H | Recombinant Human TIMP1 Protein | +Inquiry |
TIMP1-5733R | Recombinant Rat TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
TIMP1-4536R | Recombinant Rhesus Macaque TIMP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
TIMP1-92H | Native Human TIMP-1 | +Inquiry |
TIMP1-30840TH | Native Human TIMP1 | +Inquiry |
TIMP1-91B | Active Native Bovine Thrombin | +Inquiry |
◆ Lysates | ||
TIMP1-1490RCL | Recombinant Rat TIMP1 cell lysate | +Inquiry |
TIMP1-2678HCL | Recombinant Human TIMP1 cell lysate | +Inquiry |
TIMP1-2376MCL | Recombinant Mouse TIMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.
TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.
FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.
TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.
TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.
Customer Reviews (3)
Write a reviewThe efficient delivery of this product ensured that our research timelines were met without any complications.
Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.
This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.
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