Recombinant Human Janus Kinase 1, GST-tagged
Cat.No. : | JAK1-674H |
Product Overview : | Recombinant Human Janus Kinase 1 with a GST Tag at N-terminal is expressed inBaculovirus.MW=62 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | JAK1-674H |
Description : | JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. |
Source : | Baculovirus. |
Purity : | 73 %. The purity was assessed by SDS-PAGE/CBB staining. |
Buffer : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5. |
Storage And Handling : | Store at -80oC.Avoid repeating freeze-thaws. |
Gene Name : | JAK1 Janus kinase 1 [ Homo sapiens ] |
Synonyms : | JAK1; Janus kinase 1; JAK-1; Janus kinase 1 (a protein tyrosine kinase); tyrosine-protein kinase JAK1; JAK1A; JAK1B; JTK3; EC 2.7.10.2 |
Gene ID : | 3716 |
mRNA Refseq : | NM_002227 |
Protein Refseq : | NP_002218 |
MIM : | 147795 |
UniProt ID : | P23458 |
Chromosome Location : | 1p32.3-p31.3 |
Pathway : | Jak-STAT signaling pathway; Leishmaniasis; Pancreatic cancer; Pathways in cancer |
Function : | ATP binding; Janus kinase activity; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
JAK1-2147R | Recombinant Rhesus Macaque JAK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Jak1-3626M | Recombinant Mouse Jak1 Protein, Myc/DDK-tagged | +Inquiry |
JAK1-1227H | Recombinant Human JAK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
JAK1-1941H | Recombinant Human JAK1 Protein (850-1154 aa), His-tagged | +Inquiry |
Jak1-7876M | Recombinant Mouse Jak1 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
JAK1-5107HCL | Recombinant Human JAK1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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