Recombinant Human PCBD1, His-tagged
Cat.No. : | PCBD1-2809H |
Product Overview : | Recombinant human PCBD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 14.1 kDa (124aa), confirmed by MALDI-TOF. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PCBD1-2809H |
Description : | Pterin-4-alpha-carbinolamine dehydratase precursor, also known as PCBD1, is a component of the phenylalanine hydroxylase (PAH) system and participates in tetrahydrobiopterin biosynthesis. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). |
Source : | E.coli. |
Sequences Of Amino Acids : | MGSSHHHHHH SSGLVPRGSH MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT |
Purity : | > 95% by SDS – PAGE. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol. |
Concentration : | 1 mg/ml (determined by Bradford assay). |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha [ Homo sapiens ] |
Synonyms : | PCBD1; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; PCD; PHS; DCOH; PCBD; pterin-4-alpha-carbinolamine dehydratase; dimerizing cofactor for HNF1; dimerization cofactor of HNF1; 4-alpha-hydroxy-tetrahydropterin dehydratase; phenylalanine hydroxylase-stimulating protein; 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); EC 4.2.1.96; pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1); Pterin-4a-carbinolamine dehydratase (dimerization cofactor of hepatic nuclear factor 1-alpha); Pterin carbinolamine dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha |
Gene ID : | 5092 |
mRNA Refseq : | NM_000281 |
Protein Refseq : | NP_000272 |
MIM : | 126090 |
UniProt ID : | P61457 |
Chromosome Location : | 10q22 |
Pathway : | Metabolism of amino acids and derivatives |
Function : | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; identical protein binding; lyase activity; phenylalanine 4-monooxygenase activity; protein binding; transcription coactivator activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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