Active Recombinant Human Iinterferon, Beta 1, Fibroblast
Cat.No. : | IFNB1-93H |
Product Overview : | Recombinant Human interferon-beta-1b (IFN-β-1b) produced in Pseudomonas fluorescens contains a Cys17Ser substitution; and after expression, lacks the N-terminal methionine. MW = 19.9 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IFNB1-93H |
Description : | Human interferon beta (IFN-β) is produced in many cell types in response to viral infection, microorganisms, double-stranded RNA, and certain cytokines. IFN-β is known to regulate genes involved in antiviral, antiproliferative, and immunomodulatory activities. Endogenously expressed IFN-β-1a is a glycoprotein; however, nonglycosylated versions have demonstrated similar activities. |
Source : | Pseudomonas fluorescens. |
N-terminal Sequence : | Ser-Tyr-Asn-Leu-Leu. |
Purity : | >97%, by SDS-CGE under reducing condition. |
Formulation : | Lyophilized with sucrose and glycine. |
Endotoxin Level : | <1.0 EU per 1 μg of the protein by the LAL method. |
Activity : | Measured in a viral inhibition (CPE) assay using EMC virus on A549 cells. Measured in an interferon receptor-2 binding assay. |
Storage : | Store at 2-8°C upon receipt, preferably desiccated. Reconstitute aseptically in sterile 20 mM acetic acid, pH 4.0, to a final IFN-β concentration of 0.15-0.25 mg/mL. A carrier (such as albumin) is recommended if further dilution is needed. Store reconstituted IFN-β at -20°C (not in a frost-free freezer). Avoid repeated freeze-thaw. |
Gene Name : | IFNB1 interferon, beta 1, fibroblast [ Homo sapiens ] |
Synonyms : | IFNB1; interferon, beta 1, fibroblast; IFB; IFF; IFNB; MGC96956; interferon beta; IFN-beta; fibroblast interferon |
Gene ID : | 3456 |
mRNA Refseq : | NM_002176 |
Protein Refseq : | NP_002167 |
MIM : | 147640 |
UniProt ID : | P01574 |
Chromosome Location : | 9p21 |
Pathway : | Chagas disease; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway |
Function : | cytokine activity; interferon-alpha/beta receptor binding; transcription corepressor activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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