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Recombinant Human Phosphomannomutase 2, His-tagged

Cat.No. : PMM2-2822H
Product Overview : Recombinant humanPMM2 protein,fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 30.2 kDa (266aa), confirmed by MALDI-TOF.
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Cat. No. : PMM2-2822H
Description : PMM2, also known asPhosphomannomutase 2, belongs to the eukaryotic PMM family. PMM2 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. It catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mutations in PMM2 are associated with Congenital disorders of glycosylation (CDG)-Ia, an autosomal recessive disorder characterized by central nervous system dysfunction and multiorgan failure.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
Purity : > 95% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT, 0.1M NaCl.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : PMM2 phosphomannomutase 2 [ Homo sapiens ]
Synonyms : PMM2; phosphomannomutase 2; CDG1; CDGS; CDG1a; PMM 2; EC 5.4.2.8; CDG1A
Gene ID : 5373
mRNA Refseq : NM_000303
Protein Refseq : NP_000294
MIM : 601785
UniProt ID : O15305
Chromosome Location : 16p13
Pathway : Amino sugar and nucleotide sugar metabolism; Fructose and mannose metabolism; Metabolic pathways
Function : isomerase activity; phosphomannomutase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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