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Recombinant Human Protein Kinase N1, GST-His

Cat.No. : PKN1-704H
Product Overview : Recombinant Human PKN1, Amino acids M1-C942, N-terminally fused to GST-HIS6-Thrombin cleavage site, was expressed inSf9cells.MW = 136,910 Da.
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Cat. No. : PKN1-704H
Description : The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis.
Source : Baculovirus infected Sf9 cells.
Purification : One-step affinity purification using GSH-agarose.
Product Identity : PRK1 was confirmed as PRK1 by specific Western Blotting using anti PRK1 antibody.
Storage Buffer : 50 mM Tris-HCl, pH 8.0; 100 mM NaCl, 5 mM DTT, 4 mM reduced glutathione, 20% glycerol.
Concentration : 0.164 μg/μl (Bradford method using BSA [Sigma, cat#A-7638, Lot 79H7641] as standard protein).
Specific Activity : 2 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
Gene Name : PKN1 protein kinase N1 [ Homo sapiens ]
Synonyms : PKN1; protein kinase N1; DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; MGC46204; PKN-ALPHA; serine/threonine-protein kinase N1; protein kinase C-like 1; protein kinase PKN-alpha; protein kinase C-like PKN; serine-threonine kinase N; protease-activated kinase 1; protein kinase C-related kinase 1; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine protein kinase N; EC 2.7.11.13
Gene ID : 5585
mRNA Refseq : NM_002741
Protein Refseq : NP_002732
MIM : 601032
UniProt ID : Q16512
Chromosome Location : 19p13.1-p12
Function : ATP binding; GTP-Rho binding; Rac GTPase binding; androgen receptor binding; chromatin binding; histone binding; histone deacetylase binding; histone kinase activity (H3-T11 specific); ligand-dependent nuclear receptor transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; protein binding; protein kinase C activity; protein kinase C binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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