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Cat.No.
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CPBT-49944RH
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Product Overview
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Rabbit Polyclonal antibody to Human XRCC3.
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Antigen Description
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This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
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Isotype
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IgG
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Immunogen
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Recombinant protein fragment contain a sequence corresponding to a region within amino acids 202 and 346 of XRCC3
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Host
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Rabbit
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Species
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Human
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Formulation
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Liquid
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Purity Detail
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Immunogen affinity purified
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Applications
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WB, ICC/IF
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Storage buffer
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Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
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Storage
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Store at -20oC or lower.Aliquot to avoid repeated freezing and thawing.
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Sequence similarities
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Belongs to the recA family. RAD51 subfamily.
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Antigen Gene Information
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Gene Name
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XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 [ Homo sapiens ]
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Official Symbol
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XRCC3
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Synonyms
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XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; DNA repair protein XRCC3; RAD51 like; DNA repair protein XRCC3; RAD51 like; X ray repair complementing defective repair in Chinese hamster; X ray repair complementing defective repair in Chinese hamster cells 3; X ray repair cross complementing protein 3; X-ray repair cross-complementing protein 3; XRCC 3; XRCC3; XRCC3_HUMAN; X-ray repair cross-complementing protein 3; CMM6;
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GeneID
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7517
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mRNA Refseq
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NM_001100119
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Protein Refseq
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NP_001093589
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MIM
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600675
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Uniprot ID
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O43542
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Chromosome Location
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14q32.3
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Pathway
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Fluoropyrimidine Activity, organism-specific biosystem; Homologous recombination, organism-specific biosystem; Homologous recombination, conserved biosystem;
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Function
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ATP binding; DNA binding; DNA-dependent ATPase activity; nucleotide binding;
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Download Datasheet:
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