Recombinant Human Neuregulin 1
Cat.No. : | NRG1-2675H |
Product Overview : | Recombinant Human NRG1 is expressed inE. coli. |
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- Gene Information
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Cat. No. : | NRG1-2675H |
Description : | Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. |
Source : | E. coli. |
MW : | 44kDa (full length) and 30kDa (extracellular domain). |
Purity : | Over 95% pure by PAGE. |
Species Reactivity : | Human and Mouse. |
Applications : | • Western Blotting (As a positive control) • Stimulation of Tyrosine Kinase Activity of Erbs (Protein at 5nM) • Cell Proliferation and Differentiation (Protein at 5nM: dilute 5μg of stock protein to 30ml of culture medium). |
Positive Control : | T47-D breast cancer cells. |
Formulation : | Solution at 0.30 mg/ml in 20% glycerol. |
Activity : | It may be used on the repair of RNA-polymerase II transcribed genes. |
Storage : | Store vial at -20°C to -70°C. When stored at the recommended temperature, this protein is stable for 24 months. |
Gene Name : | NRG1 neuregulin 1 [ Homo sapiens ] |
Synonyms : | neuregulin 1; NRG1; GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; pro-neuregulin-1; membrane-bound isoform; pro-NRG1; glial growth factor; neu differentiation factor; sensory and motor neuron derived factor; heregulin, alpha (45kD, ERBB2 p185-activator); pro-NRG1 |
Gene ID : | 3084 |
mRNA Refseq : | NM_001159995 |
Protein Refseq : | NP_001153467 |
MIM : | 603013 |
UniProt ID : | Q02297 |
Chromosome Location : | 8p12 |
Pathway : | ErbB signaling pathway |
Function : | cytokine activity; growth factor activity; protein binding; receptor tyrosine kinase binding; transcription cofactor activity; transmembrane receptor protein tyrosine kinase activator activity |
Products Types
◆ Recombinant Protein | ||
NRG1-2510H | Recombinant Human NRG1 Protein, His-tagged | +Inquiry |
Nrg1-6199M | Recombinant Mouse Nrg1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NRG1-154C | Active Recombinant Canine NRG1 protein(Ser19-Lys240), His-tagged | +Inquiry |
Nrg1-1860R | Recombinant Rat Nrg1 Protein, His&GST-tagged | +Inquiry |
NRG1-142H | Recombinant Human NRG1 Protein (Ser20-Lys241), Animal-free, Carrier-free | +Inquiry |
◆ Lysates | ||
NRG1-836CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-1592HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-1599HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
Customer Reviews (3)
Write a reviewExcellent results, very consistent.
Worked great in assays.
Great product, very reliable.
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