Recombinant Human Neuregulin 2

• Cat.No.: NRG2-2695H
• Product Overview: Recombinant Human Neuregulin 2 is expressed inE. coli.MW= 44kDa.

Specification

• Cat. No.: NRG2-2695H
• Description: This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described.
• Source: E. coli.
• Species Reactivity: Human, Mouse.
• Applications: Western Blotting (as a positive control); Stimulation of Tyrosine Kinase Activity of Erbs(1nM; More potent than Heregulin α1); Cell Proliferation and Differentiation (1nM)(For 1nM concentration, dilute 1μg of stock protein to 33 ml of culture medium).
• Supplied As: Purified Heregulin β1 is packaged in physiological saline, pH 7.4, with 0.2% BSA. Note that this product is supplied without Sodium azide or any other preservative.
• Storage: Store vial at -20°C to -70°C. When stored at the recommended temperature, this protein is stable for 24 months.

Gene Information

• Gene Name: NRG2 neuregulin 2 [ Homo sapiens ]
• Synonyms:
  NRG2; neuregulin 2; DON1; HRG2; NTAK; OTTHUMP00000198728; divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; pro-NRG2; pro-neuregulin-2, membrane-bound isoform
• Gene ID: 9542
• mRNA Refseq: NM_001184935
• Protein Refseq: NP_001171864
• MIM: 603818
• UniProt ID: O14511
• Chromosome Location: 5q23-q33
• Pathway: ErbB signaling pathway
• Function: growth factor activity; receptor binding