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Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A)

Cat.No. : IGF2-450H
Product Overview : Recombinant Human Insulin-like Growth Factor 2 (Somatomedin A) is expressed inE.coli.
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Cat. No. : IGF2-450H
Description : Human Des(1-6) Insulin-like Growth Factor-II (Des(1-6)IGF-II) is a 61 amino acid analog of human IGF-II, lacking the first six N-terminal amino acids. This analog of IGF-II binds to the Type 1 and Type 2 IGF receptors with similar affinity to IGF-II. Human Des(1-6)IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs), which modulate the actions of IGFs.
Source : E.coli.
Molecular Weight : 6765 daltons – confirmed by Mass Spectrometry.
N-terminal Sequence Analysis : 5 residues > 95 % single sequence.
Purity : > 95 % (by HPLC and N-terminal sequence analysis).
Biological Activity : Type 1 IGF receptor binding assay: ED50 < 50 ng/ml; Type 2 IGF receptor binding assay: ED50 < 100 ng/ml;IGF binding protein assay: ED50 > 1000 ng/ml; Stimulation of protein synthesis in rat L6 myoblasts: ED50 < 75 ng/ml.
Endotoxin : < 0.1 EU/µg.
State And Appearance : Lyophilized white powder. Dried from 0.1 M acetic acid and stored under nitrogen at a slight vacuum.
Detection : Determination of IGF-I or IGF-II in a Range of Species by Radioimmunoassay (RIA).
Reconstitution : Handling of Novozymes GroPep IGF-I, IGF-II and IGF Analogs.
Storage/Stability : At least 2 years at 2 - 4°C (lyophilized).
Gene Name : IGF2 insulin-like growth factor 2 (somatomedin A) [ Homo sapiens ]
Synonyms : insulin-like growth factor 2 (somatomedin A);INSIGF; pp9974; C11orf43; FLJ22066; FLJ44734; IGF2; insulin-like growth factor 2; IGF-II; somatomedin A; somatomedin-A; insulin-like growth factor II; insulin-like growth factor type 2; putative insulin-like growth factor II associated protein; chromosome 11 open reading frame 43; OTTHUMP00000011157; OTTHUMP00000011018
Gene ID : 3481
mRNA Refseq : NM_000612
Protein Refseq : NP_000603
MIM : 147470
UniProt ID : P01344
Chromosome Location : 11p15.5
Pathway : Diabetes pathways
Function : growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can IGF2 be used as a predictive marker for certain diseases? 11/12/2021

Yes, IGF2 levels may serve as predictive markers for certain diseases. Monitoring its expression could help identify individuals at risk or track disease progression.

How can IGF2 be targeted for therapeutic interventions? 04/20/2021

Researchers are exploring various approaches, including drug development, to modulate IGF2 levels for therapeutic purposes. This may involve targeting its receptors or modifying its expression.

How does IGF2 relate to aging and age-related diseases? 12/28/2020

IGF2 has been linked to the aging process and age-related diseases. Exploring its role may provide insights into slowing down aging or managing age-related conditions.

Are there therapeutic applications of IGF2 in regenerative medicine? 12/08/2020

Research is exploring the potential use of IGF2 in regenerative medicine due to its role in cell growth and tissue repair. It may offer new avenues for tissue regeneration.

Are there clinical trials exploring IGF2 as a therapeutic target? 05/21/2019

Yes, there are ongoing clinical trials investigating the use of IGF2 in various conditions. These trials aim to assess its safety and efficacy in a clinical setting.

Customer Reviews (3)

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01/24/2023

    The IGF2 protein is an exceptional choice that meets the highest standards of quality, making it perfectly suited for your experimental needs.

    01/26/2019

      The IGF2 protein is of the highest quality and perfectly suited for your experimental requirements.

      01/20/2019

        In addition to its exceptional quality, the IGF2 protein is backed by excellent technical support offered by the manufacturer.

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