Recombinant Human IGF2, 1-104 aa

• Cat.No.: IGF2-462H
• Product Overview: Recombinant Human IGF2 (1-104aa) is expressed inE. coli.

Specification

• Cat. No.: IGF2-462H
• Description: The IGF-II gene encodes a single transcript which results in an 156 amino acid protein, including an 89 amino acid E-domain. ProIGF-II contains sites of O-linked glycosylation. ProIGF-II is converted to mature IGF-II by sequential cleavage after amino acids 104, 87 and 67. Differential glycosylation and cleavage within the E-domain can therefore result in multiple proIGF-II isoforms.The proIGF-II proteins make up 10-20% of circulating IGF-II. ProIGF-II proteins are secreted by some tumor cell lines and levels are elevated in non-islet cell tumor hypoglycemia.
• Source: Produced recombinantly inE. coli.
• Molecular Weight: 11949 Da.
• N-terminal Sequence Analysis: 5 residues > 95 % single sequence.
• Purity: > 95% by HPLC and N-terminal sequence.
• Biological Activity: Stimulation of protein synthesis in rat L6 myoblasts. Endotoxin:< 0.1 EU/ug.
• State And Appearance: Lyophilized white powder.Dried from 0.1M acetic acid under dry nitrogen at a slight vacuum (-25 kPa).
• Detection: By Western blot Peptide can be biotinylated by ibt upon request.
• Storage/Stability: At least 2 years at 2 - 4oC (lyophillized).

Gene Information

• Gene Name: IGF2 insulin-like growth factor 2 (somatomedin A) [ Homo sapiens ]
• Synonyms: insulin-like growth factor 2 (somatomedin A);INSIGF; pp9974; C11orf43; FLJ22066; FLJ44734; IGF2; insulin-like growth factor 2; IGF-II; somatomedin A; somatomedin-A; insulin-like growth factor II; insulin-like growth factor type 2; putative insulin-like growth factor II associated protein; chromosome 11 open reading frame 43; OTTHUMP00000011157; OTTHUMP00000011018
• Gene ID: 3481
• mRNA Refseq: NM_000612
• Protein Refseq: NP_000603
• MIM: 147470
• UniProt ID: P01344
• Chromosome Location: 11p15.5
• Pathway: Diabetes pathways
• Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding