Active Recombinant Human MAX Dimerization Protein 1

• Cat.No.: MXD1-2502H
• Product Overview: Recombinant human MAD was expressed in anE. colisystem and purified by an affinity column in combination with FPLC chromatography. 24 kDa.

Specification

• Cat. No.: MXD1-2502H
• Description: MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with Myc for binding to MAX to form a sequence-specific DNA-binding complex, acting as a transcriptional repressor (while Myc appears to function as an activator) and is a candidate tumor suppressor. Both Myc and MAD, as well as the more recently described Mnt and Mga proteins, form heterodimers with MAX, permitting binding to specific DNA sequences. These DNA-bound heterodimers recruit coactivator or corepressor complexes that generate alterations in chromatin structure, which in turn modulate transcription. The wild-type c-Myc and c-Myc/MADBR proteins have indistinguishable biological activity and target gene recognition in vivo .
• Source: E. coli.
• Applications: MAD can be applied to DNA binding, proliferation, differentiation, and apoptosis research studies.
• Activity: 1 unit equals 1 nanogram of purified protein.
• Quality Control: The purified protein is greater than 95% homogeneous based on SDS-PAGE gel analysis.
• Reagents Supplied: 1x dilution buffer A: 20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 0.2 mM EDTA and 1mM DTT.
• Storage Conditions: Store at -80°C.

Gene Information

• Gene Name: MXD1 MAX dimerization protein 1 [ Homo sapiens ]
• Synonyms: MAX dimerization protein 1; MAD; MAD1; MGC104659; MXD1; max dimerization protein 1; max dimerizer 1; OTTHUMP00000202211; MAD protein (MAX-binding protein); MAX dimerizer
• Gene ID: 4084
• mRNA Refseq: NM_002357
• Protein Refseq: NP_002348
• MIM: 600021
• UniProt ID: Q05195
• Chromosome Location: 2p13-p12
• Function: protein binding; transcription cofactor activity; transcription corepressor activity; transcription factor activity