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Recombinant Human Calcyclin Binding Protein, His-tagged

Cat.No. : CACYBP-54H
Product Overview : Recombinant human CACYBP protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =23.4 kDa (205aa).
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Cat. No. : CACYBP-54H
Description : CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in Ubiquitin E3 complexes. It also participates in the Ubiquitin-mediated degradation of β-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on β-catenin protein expression and transcriptional activation of TCF/LEF.
Source : E.coli.
Form : Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT, 0.1M NaCl.
Purity : > 85% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : CACYBP calcyclin binding protein [ Homo sapiens ]
Synonyms : calcyclin binding protein; SIP; GIG5; MGC87971; PNAS-107; S100A6BP; RP1-102G20.6; CACYBP; calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein;OTTHUMP00000201857; Siah-interacting protein; CacyBP
Gene ID : 27101
mRNA Refseq : NM_001007214
Protein Refseq : NP_001007215
MIM : 606186
UniProt ID : Q9HB71
Chromosome Location : 1q24-q25
Pathway : Wnt signaling pathway
Function : protein binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the phosphorylation of CACYBP influence its biochemical properties and cellular functions? 01/17/2022

Phosphorylation of CACYBP can modulate its protein-protein interactions and stability. Phosphorylation events may affect its role in cell cycle regulation and ubiquitin-dependent protein degradation.

How does CACYBP's calcium-binding capability influence its conformational dynamics and interactions with calcium-dependent proteins? 07/30/2020

CACYBP's calcium-binding domains undergo conformational changes upon calcium binding, which can affect its interactions with other proteins. It allows CACYBP to act as a calcium-dependent scaffold for various signaling complexes.

What are the biochemical mechanisms underlying the influence of CACYBP on cell cycle progression, including its interactions with Cyclins and CDKs? 11/25/2019

CACYBP interacts with Cyclins and CDKs, forming complexes that regulate the phosphorylation of key cell cycle regulators. These interactions affect the progression through different phases of the cell cycle.

Can you explain the role of CACYBP in ubiquitin-dependent protein degradation and its connection to the proteasome system? 04/09/2019

CACYBP functions as an adaptor protein in ubiquitin-dependent protein degradation by facilitating the transfer of ubiquitin moieties to target proteins. It forms complexes with E3 ubiquitin ligases and substrates, directing them to the proteasome for degradation.

Can you discuss the role of CACYBP in cellular responses to stress, including oxidative stress and DNA damage, and its molecular mechanisms in these contexts? 12/08/2018

CACYBP participates in stress responses by modulating the stability and activity of proteins involved in stress pathways. For example, it can influence the stability of DNA repair proteins and oxidative stress response factors, contributing to cellular adaptation to stress conditions.

Customer Reviews (3)

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Reviews
11/15/2021

    I saw results within weeks.

    04/19/2020

      Impressed with the results.

      07/06/2018

        High-quality product.

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