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Recombinant Human Matrix Metallopeptidase 9

Cat.No. : MMP9-709H
Product Overview : Recombinant human matrix metallopeptidase 9 was expressed inNSO Cells.
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Cat. No. : MMP9-709H
Description : Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases and tumor invasion. MMPs are synthesized as enzymogen and converted to active form by other MMPs or extracellular proteinases. MMP9, also known as 92-kDa gelatinase B/type IV collagenase, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. It contains a fibronectin-like domain, which functions in the binding of gelatin, a unique serine/proline/threonine-rich collagen type V-like domain probably serving as attachment sites of multiple O-linked oligosaccharides and a carboxyl terminal hemopexin-like domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin.
Source : Mammalian cells
Assay : >95% (SDS-PAGE).
Form : Buffered aqueous solution.
Mol wt : Apparent mol wt ~93 kDa.
Shipped In : Dry ice.
Storage Temp : −70℃.
Personal Protective Equipment : Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Gene Name : MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [ Homo sapiens ]
Synonyms : MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; MMP-9; EC 3.4.24.35; OTTHUMP00000031674; 92 kDa gelatinase 3; 92 kDa type IV collagenase; Gelatinase B; macrophage gelatinase 2; type V collagenase
Gene ID : 4318
mRNA Refseq : NM_004994
Protein Refseq : NP_004985
MIM : 120361
UniProt ID : P14780
Chromosome Location : 20q12-q13
Pathway : Bladder cancer; Pathways in cancer; Leukocyte transendothelial migration
Function : calcium ion binding; collagen binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the consequences of dysregulated MMP9 expression in cancer progression? 02/13/2022

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity? 09/07/2021

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level? 01/17/2020

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders? 11/14/2019

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level? 06/02/2018

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.

Customer Reviews (3)

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Reviews
05/03/2020

    The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

    08/15/2019

      Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

      01/21/2018

        Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

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