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Recombinant Human Klotho, Extracellular Domain, Fc Chimera

Cat.No. : KL-2155H
Product Overview : Recombinant the signal peptide and the extracellular domain of human Klotho (aa 1-981) produced inHEK 293cells are fused at the C-terminus to the Fc portion of human IgG.
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Cat. No. : KL-2155H
Description : Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid.
Source : HEK 293.
Purity : ≥90% (SDS-PAGE).
Formulation : Liquid. 0.2μm-filtered solution in PBS.
Concentration : ~0.15mg/ml.
Endotoxin Content : <1EU/µg protein (LAL-test).
Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Gene Name : KL klotho [ Homo sapiens ]
Synonyms : KL; klotho; EC 3.2.1.31; Klotho peptide; OTTHUMP00000018796
Gene ID : 9365
mRNA Refseq : NM_004795
Protein Refseq : NP_004786
MIM : 604824
UniProt ID : Q9UEF7
Chromosome Location : 13q12
Pathway : Signaling by FGFR
Function : beta-glucosidase activity; beta-glucuronidase activity; cation binding; fibroblast growth factor binding; hormone activity; protein binding; signal transducer activity; vitamin D binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does KL protein affect cognitive function? 04/08/2022

KL protein may have a neuroprotective role and is being studied for its potential in preserving cognitive function and preventing neurodegenerative diseases.

Are there any KL protein-based therapies available for clinical use? 04/07/2022

Currently, there are no FDA-approved KL protein-based therapies, but research in this area is ongoing.

Can KL protein supplementation slow down the aging process? 10/25/2021

While research suggests a connection between KL protein and aging, it is not yet clear if KL protein supplementation can effectively slow down the aging process in humans.

How is KL protein measured in clinical settings? 07/19/2018

KL protein levels can be measured in blood and urine samples using various laboratory techniques.

Are there any clinical trials exploring KL protein-based therapies? 04/28/2016

Yes, several clinical trials are investigating the potential therapeutic benefits of KL protein supplementation in kidney disease and other disorders.

Customer Reviews (3)

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Reviews
01/31/2021

    The KL protein's reliability and ease of use have made it an essential component of my structural investigations.

    01/22/2019

      Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

      07/22/2016

        Furthermore, the KL protein has demonstrated great utility in protein electron microscopy structure analysis.

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