Recombinant Human UBA7, His-tagged
Cat.No. : | UBA7-629H |
Product Overview : | Recombinant Human UBA7 isproduced inE. coliand fused at the C-terminus to a His-tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | UBA7-629H |
Description : | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. |
Source : | E. coli. |
Purity : | >95%. Purified by Ni-affinity chromatography. |
Application : | Activation of ISG15 for ISGylation of specific proteins in presence of dedicated E2 conjugating/E3 ligase enzymes. ISGylation pathway studies. Test proteins for ISG15 E3 ligase activity. Test proteins as potential targets for ISG15 modification. |
Storage : | -80°C. |
Gene Name : | UBA7 ubiquitin-like modifier activating enzyme 7 [ Homo sapiens ] |
Synonyms : | UBA7; ubiquitin-like modifier activating enzyme 7; UBA1, ubiquitin-activating enzyme E1 homolog B; UBA7, ubiquitin-activating enzyme E1; ubiquitin-activating enzyme 7; ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-like; ubiquitin-activating enzyme E1-related protein; ubiquitin-activating enzyme-2; ubiquitin-like modifier-activating enzyme 7; D8; UBE2; UBA1B; UBE1L; MGC12713 |
Gene ID : | 7318 |
mRNA Refseq : | NM_003335 |
Protein Refseq : | NP_003326 |
MIM : | 191325 |
UniProt ID : | P41226 |
Chromosome Location : | 3p21 |
Pathway : | Parkinson"s disease; Ubiquitin mediated proteolysis |
Function : | ATP binding; ISG15 activating enzyme activity; ligase activity; nucleotide binding |
Products Types
◆ Recombinant Protein | ||
UBA7-0050H | Recombinant Human UBA7 Protein (D2-L1012), Tag Free | +Inquiry |
Uba7-6770M | Recombinant Mouse Uba7 Protein, Myc/DDK-tagged | +Inquiry |
UBA7-2291H | Recombinant Human UBA7 Protein, His (Fc)-Avi-tagged | +Inquiry |
UBA7-0051H | Recombinant Human UBA7 Protein (D2-L1012), His/Strep tagged | +Inquiry |
Uba7-5757R | Recombinant Rat Uba7 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
UBA7-601HCL | Recombinant Human UBA7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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