Recombinant Human SERPINA3 protein, His-tagged
Cat.No. : | SERPINA3-665H |
Product Overview : | Recombinant Human SERPINA3 (His24-Ala423) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | Serpin A3 is also known as Alpha-1-antichymotrypsin (ACT or AACT), Cell growth-inhibiting gene 24/25 protein, which belongs to the serpin family. Serpin A3 can bind DNA. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | His24 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 46.6 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | His24-Ala423 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | SERPINA3 |
Official Symbol : | SERPINA3 |
Synonyms : | SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; AACT, alpha 1 antichymotrypsin , serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3; alpha-1-antichymotrypsin; ACT; alpha 1 antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; AACT; GIG24; GIG25; MGC88254 |
Gene ID : | 12 |
mRNA Refseq : | NM_001085 |
Protein Refseq : | NP_001076 |
MIM : | 107280 |
UniProt ID : | P01011 |
Products Types
◆ Recombinant Protein | ||
SERPINA3-571H | Recombinant Human SERPINA3 Protein, His-tagged | +Inquiry |
SERPINA3-2H | Recombinant Horse SERPINA3 Protein, His (Fc)-Avi-tagged | +Inquiry |
SERPINA3-257H | Recombinant Horse SERPINA3 protein, His-tagged | +Inquiry |
SERPINA3-3239M | Recombinant Mouse SERPINA3 protein, His-tagged | +Inquiry |
SERPINA3-5611H | Recombinant Human SERPINA3 Protein (Lys235-Arg394), N-GST tagged | +Inquiry |
◆ Native Protein | ||
SERPINA3-5331H | Native Human Serpin Peptidase Inhibitor, Clade A (alpha-1 antiproteinase, antitrypsin), Member 3 | +Inquiry |
SERPINA3-8349H | Native Human SERPINA3 | +Inquiry |
SERPINA3-8008H | Native Human Serum Alpha 1-AntiChymoTrypsin | +Inquiry |
◆ Lysates | ||
SERPINA3-2522HCL | Recombinant Human SERPINA3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionSerpina3n plays significant roles in various physiological processes, including modulation of the complement cascade, apoptosis, wound healing, and potential implications in Alzheimer's disease.
Recent studies have reported significant roles of Serpina3n during various pathologies, particularly in central nervous system (CNS) insults, making it a potential therapeutic target.
The aim is to compile literature shedding light on the potential therapeutic applications of Serpina3n/SERPINA3 in various diseases. Additionally, a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) is provided to account for their biological roles and significance.
The full range of potential applications of Serpina3n is yet to be fully revealed, but its reported implications, especially in CNS insults, suggest potential therapeutic applications.
Serpina3n is a secretory serine protease inhibitor belonging to clade "a" with unique structural and physiological characteristics. |
Serpina3n inhibits a wide range of proteases, contributing to its diverse physiological roles.
Serpina3n belongs to clade "a" of serine protease inhibitors. |
Customer Reviews (3)
Write a reviewThe product's impact extended to data analysis, with intuitive tools for interpreting experimental results.
The longevity of the product's effects allowed us to study cellular responses over extended timeframes.
We found that the product's support for data analysis and visualization significantly expedited our research.
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