Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human SERPINA3 protein, His-tagged

Cat.No. : SERPINA3-665H
Product Overview : Recombinant Human SERPINA3 (His24-Ala423) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : Serpin A3 is also known as Alpha-1-antichymotrypsin (ACT or AACT), Cell growth-inhibiting gene 24/25 protein, which belongs to the serpin family. Serpin A3 can bind DNA. Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : His24
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 46.6 kDa. The protein migrates as 50-63 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : His24-Ala423
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : SERPINA3
Official Symbol : SERPINA3
Synonyms : SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; AACT, alpha 1 antichymotrypsin , serine (or cysteine) proteinase inhibitor, clade A (alpha 1 antiproteinase, antitrypsin), member 3; alpha-1-antichymotrypsin; ACT; alpha 1 antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3; AACT; GIG24; GIG25; MGC88254
Gene ID : 12
mRNA Refseq : NM_001085
Protein Refseq : NP_001076
MIM : 107280
UniProt ID : P01011

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
What are the physiological roles of Serpina3n? 10/13/2022

Serpina3n plays significant roles in various physiological processes, including modulation of the complement cascade, apoptosis, wound healing, and potential implications in Alzheimer's disease.

What is the significance of Serpina3n in pathologies? 03/31/2022

Recent studies have reported significant roles of Serpina3n during various pathologies, particularly in central nervous system (CNS) insults, making it a potential therapeutic target.

What is the aim of literature drawing together Serpina3n applications? 03/26/2021

The aim is to compile literature shedding light on the potential therapeutic applications of Serpina3n/SERPINA3 in various diseases. Additionally, a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) is provided to account for their biological roles and significance.

Are the full range of Serpina3n applications known? 07/21/2020

The full range of potential applications of Serpina3n is yet to be fully revealed, but its reported implications, especially in CNS insults, suggest potential therapeutic applications.

What is Serpina3n? 05/06/2020

Serpina3n is a secretory serine protease inhibitor belonging to clade "a" with unique structural and physiological characteristics. |

How does Serpina3n inhibit proteases? 05/12/2017

Serpina3n inhibits a wide range of proteases, contributing to its diverse physiological roles.

To which clade does Serpina3n belong? 03/07/2016

Serpina3n belongs to clade "a" of serine protease inhibitors. |

Customer Reviews (3)

Write a review
Reviews
03/14/2022

    The product's impact extended to data analysis, with intuitive tools for interpreting experimental results.

    06/14/2020

      The longevity of the product's effects allowed us to study cellular responses over extended timeframes.

      10/31/2017

        We found that the product's support for data analysis and visualization significantly expedited our research.

        Ask a Question for All SERPINA3 Products

        Required fields are marked with *

        My Review for All SERPINA3 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends