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Active Recombinant Mouse Fgfr3 protein(Met1-Tyr367), His-tagged

Cat.No. : Fgfr3-624M
Product Overview : Recombinant Mouse FGFR3 (NP_032036.2)(Met 1-Tyr 367) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.
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Source : HEK293
Species : Mouse
Tag : C-His
Protein length : Met1-Tyr367
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its ability to inhibit FGF acidic dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.3-4 μg/mL.
Molecular Mass : The recombinant mouse FGFR3 comprises 358 amino acids and has a calculated molecular mass of 37 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmFGFR3 is approximately 70-80 kDa due to glycosylation.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 98 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Fgfr3 fibroblast growth factor receptor 3 [ Mus musculus ]
Official Symbol : Fgfr3
Synonyms : FGFR3; fibroblast growth factor receptor 3; heparin-binding growth factor receptor; FR3; Mfr3; sam3; CD333; Flg-2; HBGFR; Fgfr-3;
Gene ID : 14184
mRNA Refseq : NM_001163215
Protein Refseq : NP_001156687

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FGFR3 testing assist in personalized medicine approaches? 12/13/2022

FGFR3 testing helps identify specific genetic mutations, allowing for personalized treatment plans tailored to an individual's genetic profile.

Is FGFR3 testing routinely conducted in cancer diagnosis? 06/25/2022

FGFR3 testing is becoming more common, especially in cases where specific cancers associated with FGFR3 mutations are suspected.

Can FGFR3 be a prognostic marker in cancer? 12/01/2016

Yes, FGFR3 status can serve as a prognostic marker, influencing the prediction of disease progression and patient outcomes.

Are there targeted therapies based on FGFR3 in cancer treatment? 07/23/2016

Yes, FGFR3-targeted therapies are being developed for cancer treatment, particularly for patients with FGFR3 mutations.

How is FGFR3 targeted in cancer therapy? 03/13/2016

FGFR3-targeted therapies may involve small molecule inhibitors or monoclonal antibodies that specifically block the activity of mutated FGFR3.

Customer Reviews (3)

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01/13/2020

    Researchers who have utilized FGFR3 protein praise its exceptional performance and reliability in their experiments.

    03/26/2018

      Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

      08/29/2017

        Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

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