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Cat.No.
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CPBT-52363RH
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Product Overview
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Rabbit Polyclonal antibody to Human CPLX2.
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Antigen Description
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Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene.
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Isotype
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IgG
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Immunogen
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A synthetic peptide from an internal region of Human CPLX2 conjugated to an immunogenic carrier protein.
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Host
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Rabbit
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Species
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Human
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Specificity
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Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
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Formulation
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Liquid
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Purity Detail
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Whole antiserum
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Applications
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WB, IHC-P, IHC-Fr
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Storage buffer
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Preservative: NoneConstituents: Whole serum, 1X PBS
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Storage
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Store at +4oC short term (1-2 weeks). Aliquot and store at -20oC (add glycerol to a final volume of 40% for extra stability). Avoid repeated freeze / thaw cycles.
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Sequence similarities
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Belongs to the complexin/synaphin family.
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Antigen Gene Information
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Gene Name
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CPLX2 complexin 2 [ Homo sapiens ]
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Official Symbol
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CPLX2
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Synonyms
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CPLX2; complexin 2; complexin-2; CPX 2; DKFZp547D155; 921 L; Complexin 2; Complexin II; Complexin-2; Complexin2; ComplexinII; CPLX 2; Cplx2; CPLX2_HUMAN; CPX 2; CPX II; CPXII; Hfb1; Synaphin 1; Synaphin-1; Synaphin1; CPX II; synaphin 1; synaphin-1; complexin II; CPX2; Hfb1; 921-L; CPX-2;
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GeneID
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10814
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mRNA Refseq
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NM_001008220
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Protein Refseq
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NP_001008221
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MIM
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605033
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Uniprot ID
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Q6PUV4
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Chromosome Location
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5q35.2
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Pathway
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Synaptic vesicle cycle, organism-specific biosystem; Synaptic vesicle cycle, conserved biosystem;
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Function
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syntaxin-1 binding;
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Download Datasheet:
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