FOXO Reporter Kit (PI3K/AKT Pathway)
Cat.No. : | Kit-1732 |
Product Overview : | The PI3K/AKT signaling pathway is essential for cell growth and survival. Disruption of this pathway or its regulation has been linked to a variety of cancers and coronary diseases. Mammalian FOXO protein (FOXO1, FOXO3, FOXO4), a subgroup of Forkhead transcription factors, is among the best characterized targets of the PI3K/AKT signaling pathway. These transcription factors function as a trigger for apoptosis by upregulating genes necessary for cell death. Insulin or growth factors induce activation of PI3K, which in turn activates AKT. AKT directly phosphorylates FOXOs, resulting in the export of FOXOs from the nucleus to the cytoplasm, thereby inhibiting FOXO-dependent transcription. |
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- Gene Information
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Size : | 500 reactions |
Applications : | Monitor PI3K/AKT signaling pathway activity and FOXO transcriptional activity. |
Storage : | Stable at least 12 months from date of receipt, when stored as directed (-20°C) |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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