Interleukin Structure
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- Recombinant Proteins
- Native Proteins
- GMP Proteins
- Fluorescent Dyes
- IL information
- Autoimmune Disease
- IL Pathway
- IL Family related Drugs
- IL1 Superfamily
- IL6 Family
- IL10 Family
- IL12 Family
- Interleukin-17 (IL17) Family
- Interleukin Structure
IL1 family
IL-6 family
IL10 family
IL12 family
IL17 family
Other interleukins
Structure is an important and useful character to classify evolutionarily related proteins. For interleukin, IL1-like cytokines can be identified from other cytokines by a fold rich in beta-strands. IL6, IL11, IL12A, IL23A, IL27A, IL31 and oncostatin M (OSM) are long-chain class I helical cytokines. However, IL2, IL3, IL4, IL5, IL7, IL9, IL13, IL15 and IL21 are short-chain helical cytokines. The IL10-like and IL28-like are similar in structure through a fold that contains six or seven stacked α-helices. IL17 family members are structurally unrelated to other IL subfamily. IL17F shares a high degree of sequence homology with IL17A. IL17F was recently crystalized and structural analysis, finding a cysteine-knot fold.
Related literatures
1. Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. "Evolutionary divergence and functions of the human interleukin (IL) gene family.". Human Genomics 5 (1): 30–55, OCTOBER 2010.
2. Commins, S.P., Borish, L. and Steinke, J.W. (2010), ‘Immunologic messenger molecules: Cytokines, interferons, and chemokines’, J. Allergy Clin. Immunol. Vol. 125, pp. S53–S72.
