Active GMP Recombinant Human NRG1 Protein
Cat.No. : | NRG1-139HG |
Product Overview : | Recombinant Human NRG1, Thr176-Lys246, was produced in E. coli using non-animal reagents in an animal-free facility under cGMP guidelines. |
- Specification
- Gene Information
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Source : | E. coli |
Species : | Human |
Form : | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA. |
Bio-activity : | Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. |
Molecular Mass : | Predicted Molecular Mass: 8 kDa SDS-PAGE: 8 kDa, reducing conditions |
N-terminal Sequence Analysis : | Thr-Ser-His-Leu-Val-Lys-(Cys)-Ala-Glu-Lys |
Endotoxin : | <0.01 EU per 1 μg of the protein by the LAL method. |
Purity : | >97%, by SDS-PAGE with silver staining, under reducing conditions. |
Storage : | Avoid repeated freeze-thaw cycles. 12 months, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 100 μg/mL in PBS. |
Quality Statement : | Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Gene Name : | NRG1 neuregulin 1 [ Homo sapiens ] |
Official Symbol : | NRG1 |
Synonyms : | NRG1; neuregulin 1; HGL; pro-neuregulin-1, membrane-bound isoform; GGF; HRG; NDF; MSTP131; pro-NRG1; glial growth factor; neu differentiation factor; GGF2; HRG1; HRGA; SMDF; MST131; |
Gene ID : | 3084 |
mRNA Refseq : | NM_001159995 |
Protein Refseq : | NP_001153467 |
MIM : | 142445 |
UniProt ID : | Q02297 |
Products Types
◆ Recombinant Protein | ||
NRG1-215H | Recombinant Human NRG1-β Protein | +Inquiry |
Nrg1-6199M | Recombinant Mouse Nrg1 Protein, His (Fc)-Avi-tagged | +Inquiry |
NRG1-23M | Active Recombinant Mouse Nrg1 Protein, His-tagged | +Inquiry |
NRG1-3227H | Recombinant Human NRG1 protein(Ser2-Lys246), Biotinylated | +Inquiry |
Nrg1-1860R | Recombinant Rat Nrg1 Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
NRG1-001CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
NRG1-1591HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-1675HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
Customer Reviews (3)
Write a reviewExcellent results, very consistent.
Worked great in assays.
Great product, very reliable.
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