|Product Overview:||Tetanus Toxoid was purified from Clostridium tetani.|
|Description:||Tetanus toxin is a potent neurotoxin that is taken up by presynaptic terminals at the neuromuscular junction, travels retrogradely within motor neurons and is transported transsynaptically to spinal cord interneurons. Upon entering the motor neuron, tetanus toxin associates with lipid rafts, is incorporated into non-acidified vesicles, sorted in a Rab 5/7 dependent pathway and transported to the cell body. The tetanus toxin is trancytosed so that it enters upstream inhibitory neurons where it cleaves VAMP-2, inhibiting neurotransmitter release. Tetanus toxin inhibits neurotransmitter release with great potency and selectivity, cleaving a bond in vesicle-associated membrane protein-2 (VAMP-2) or synaptobrevin-2, thereby preventing the fusion of synaptic vesicles with the presynaptic membrane. Tetanus toxoid is currently used as a vaccine to produce immunity to tetanus, the disease caused by Clostridium tetani. Additionally, tetanus toxoid functions as a carrier of conjugated polysaccharides in the development of vaccines against encapsulated bacterial pathogens.|
|Form:||Each vial, when reconstituted with 0.05 ml of water, contains 0.025 mg of protein in 0.1 M Histidine, 100mM NaCl, pH 7.0 with 5% Trehalose. Handle the product gently, do not vortex.|
|Storage:||This product is provided as a lyophilized powder, sealed under vacuum. Store at 2-8 centigrade prior to reconstitution. Following reconstitution, aliquot and freeze.|
|Warning:||Good laboratory technique should be employed in the safe handling of this product. Wear appropriate laboratory attire including a lab coat, gloves and safety glasses. Nitrile gloves are recommended when handling lyophilized material. This product is intended for research purposes by qualified personnel only. It is not intended for use in humans or as a diagnostic agent.|
Price does not include shipping and packaging costs.Request quote for final price.