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P300 Homogeneous Assay Kit

Cat.No. : Kit-1791
Product Overview : The adenovirus E1A-associated cellular p300 transcriptional co-activator protein functions as a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. p300 (also known as KAT3B) acetylates all four core histones in nucleosomes, as well as non-histone targets. p300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. p300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), which plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and its dysfunction is linked to a number of human diseases including Parkinson"s, Huntington"s, and Alzheimer"s diseases. p300 may also play a role in epithelial cancer.
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Size : 384 reactions
Applications : Great for studying enzyme activity and screening small molecular inhibitors for drug discovery and HTS applications.
Storage : Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Specific RNA targets or motifs recognized by EIF4A3 include splice sites and exon junctions, with functional significance in maintaining mRNA integrity. 10/16/2022

Specific transcription factors and coactivators, such as p53, CREB, and CBP, interact with p300, playing roles in gene expression and cellular responses.

Eukaryotic translation initiation factor 4A3 (EIF4A3) primarily functions in cellular processes, playing a role in RNA metabolism, including splicing and translation. 08/07/2022

p300 (EP300) plays a crucial role in cellular processes and gene regulation, serving as a transcriptional coactivator.

EIF4A3 contributes to the regulation of RNA metabolism by participating in splicing, translation initiation, and mRNA surveillance. 01/07/2021

p300 functions as a histone acetyltransferase (HAT), catalyzing the acetylation of histones and influencing chromatin modification.

There are potential therapeutic implications related to EIF4A3 in diseases involving RNA metabolism, making it a target for drug development. 08/10/2019

There are potential therapeutic implications related to p300 in diseases involving gene regulation, making it a target for drug development.

EIF4A3 is predominantly localized in the nucleus and cytoplasm of cells, contributing to its involvement in RNA-related processes. 02/20/2019

p300 is predominantly localized in the nucleus of cells, where it exerts its functions in gene regulation.

EIF4A3 influences the balance between mRNA quality control, including nonsense-mediated decay, and translation efficiency. 11/27/2018

p300 contributes to the regulation of cell cycle progression and apoptosis, influencing cell fate decisions.

Dysregulation or abnormal expression of EIF4A3 is associated with conditions such as cancer and neurodegenerative disorders. 11/20/2016

Dysregulation or abnormal expression of p300 is associated with various diseases, including cancer and neurodegenerative disorders.

Customer Reviews (3)

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06/26/2018

    Clear and accessible protocols made it easy for all team members to contribute to our research efforts.

    05/06/2017

      We anticipated the product's future contributions to our evolving research objectives.

      03/19/2016

        We appreciated that the product adhered to relevant regulatory standards, ensuring the ethical conduct of our experiments.

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